Silvia analyses population level pathogen genome sequences in the context of global surveillance and antimicrobial resistance, and informs the development of transitional tools for pathogen surveillance in public health.
Currently, I focus on the development of tools for global surveillance of selected Salmonella enterica serovars, which are a global public health concern. My research interests also include the relationships and exchange of genetic material between and within Streptococcus species belonging to the viridans group. I also enjoy collaborating with other researchers at the Sanger Institute to produce intuitive visualizations that enhance the benefit of high-throughput genomic data applied to pathogen evolution and epidemiology.
My research background is in opportunistic pathogens of humans, both bacterial and fungal.
Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera.
Nature communications 2015;6;8322
Characterizing Diversity of Lactobacilli Associated with Severe Early Childhood Caries: A Study Protocol.
Advances in microbiology 2015;5;1;9-20
Oral Lactobacilli and Dental Caries: A Model for Niche Adaptation in Humans.
Journal of dental research 2015;94;9 Suppl;110S-8S
Comparative genomics of oral isolates of Streptococcus mutans by in silico genome subtraction does not reveal accessory DNA associated with severe early childhood caries.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2014;21;269-78
Phylogenetic analysis of glucosyltransferases and implications for the coevolution of mutans streptococci with their mammalian hosts.
PloS one 2013;8;2;e56305
Distribution of putative virulence genes in Streptococcus mutans strains does not correlate with caries experience.
Journal of clinical microbiology 2011;49;3;984-92
Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3.
Eukaryotic cell 2011;10;2;272-5
Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicans.
Eukaryotic cell 2007;6;4;682-92
Mucor rouxii Rho1 protein; characterization and possible role in polarized growth.
Antonie van Leeuwenhoek 2007;91;3;237-51
Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans.
Molecular biology of the cell 2005;16;6;2913-25