Dr Julia Maryam Arasteh | Postdoctoral Fellow

This person is a member of Sanger Institute Alumni.

Arasteh, Julia Maryam

Maryam's research involves the functional analysis of novel genes associated with inflammatory bowel disease (IBD) using knockout animal models generated through the Mouse Genetics Project at the Wellcome Trust Sanger Institute.

IBD is a growing health concern in industrialised countries which is estimated to affect about 240,000 people in the UK alone, approximately 400 patients per 100,000 of the population (Rubin et. al. 2000 Aliment Pharmacol Ther). The hallmark of disease is chronic inflammation of the gastrointestinal tract with Ulcerative Colitis and Crohn’s Disease being the two most common forms of IBD. The exact aetiology of IBD remains unknown but both genetics and the microbial community within the gut have been shown to play a role.

Maryam's research is based on Genome wide association studies (GWAS) carried out in recent years which have identified a number of genes associated with IBD. The aim is to identify novel genes associated with disease which are also implicated in the symbiotic relationship with intestinal bacteria and to study their function in detail. The goal is to find new cellular pathways that contribute to disease and may be used as possible therapeutic targets in the future.

Publications

  • Pathogen Resistance Mediated by IL-22 Signaling at the Epithelial-Microbiota Interface.

    Schreiber F, Arasteh JM and Lawley TD

    Journal of molecular biology 2015;427;23;3676-82

  • Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.

    Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD et al.

    Cell host & microbe 2014;16;4;504-16

  • Fas gene polymorphisms in systemic lupus erythematosus and serum levels of some apoptosis-related molecules.

    Arasteh JM, Araste JM, Sarvestani EK, Aflaki E and Amirghofran Z

    Immunological investigations 2010;39;1;27-38

  • Regulation of tomato Prf by Pto-like protein kinases.

    Mucyn TS, Wu AJ, Balmuth AL, Arasteh JM and Rathjen JP

    Molecular plant-microbe interactions : MPMI 2009;22;4;391-401

  • Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.

    Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD et al.

    Cell host & microbe 2014;16;4;504-16

  • Fas gene polymorphisms in systemic lupus erythematosus and serum levels of some apoptosis-related molecules.

    Arasteh JM, Araste JM, Sarvestani EK, Aflaki E and Amirghofran Z

    Immunological investigations 2010;39;1;27-38

  • Regulation of tomato Prf by Pto-like protein kinases.

    Mucyn TS, Wu AJ, Balmuth AL, Arasteh JM and Rathjen JP

    Molecular plant-microbe interactions : MPMI 2009;22;4;391-401

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Julia Maryam's Timeline
2012

Joined the Host-Microbiota Interactions Laboratory, The Wellcome Trust Sanger Institute.

PhD in Biomedical research, BMRC, University of East Anglia, Norwich, England.

2006

MSc in Human Immunology, Shiraz University of Medical Sciences, Iran.

2002

BSc in Cellular and Molecular Biology, Shiraz University of Sciences, Iran.