Dr Carl Anderson | Group Leader and Director of Graduate Studies

Anderson, Carl

Carl is a statistical geneticist interested in using genetic and genomic data to further our understanding of immune-mediated diseases. He heads the Genomics of Inflammation and Immunity group at the Sanger Institute. He is also the Institute's Director Graduate Studies.

I have always been fascinated vy the ability of human genetic variation to identify the causal biology of disease. I believe that advancing our knoweldge of the genetic underpinnings of complex diseases has the power to revolutionise both our ability to identify effective new drug targets and identify the patients who will benefit most from these drugs. By collaborating with clinicians around the world, my team combines the analysis of whole genome sequencing with functional genomics data from disease-relevant primary cells to connect disease risk to genetics and cell biology.

I became interested in human disease genetics during my time as a biomedical sciences undergraduate at the University of Sheffield, UK. At that time I was particularly fascinated by neurodegenerative diseases, and was drawn to genetics as a means of discovering causal disease biology in an organ as mysterious as the brain. After graduating I undertook an MSc in Genetic Epidemiology, again at the University of Sheffield, to begin learning about genetic mapping. With my interest in the field then firmly established, I moved to the University of Edinburgh in 2003 to undertake a PhD in Quantitative Genetics under the supervision of Peter Visscher. I spent the final two years of my PhD in the Genetic Epidemiology Department at the University of Brisbane folllowing Peter's move there for a professiorship position. I was very fortunate that, right at the time I was finishing my PhD at the end of 2006, the Wellcome Trust Case Control Consortium (WTCCC) was on the lookout for postdocs to lead aspects of the project. I moved to Oxford at the beginning of 2007 to work on the inflammatory bowel disease arm of the WTCCC, boyed by the fact that even linkage analysis managed to map a risk locus for IBD (NOD2).

In 2009, I moved to the Sanger Institue to establish my research group on the genomics of inflammation and immunity. My team has used genome-wide association studies to identify over 280 independent risk loci for IBD, primary sclerosing cholangitis and primary biliary cirrhosis. In 2016 we opened our own wet lab to enable us to explore the cellular consequences of genetic variants associated with immune-medated disease risk and perform functional screens. We have a wide range of very exciting projects underway in our multidiscpinary team, and if you'd like to know more about these please visit www.andersonlab.info. We're always on the lookout for bright and motivated people to join the group so, if you're interested, please drop me an email and include your CV.

Publications

  • Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

    Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L et al.

    Nature genetics 2017;49;2;269-273

  • Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

    de Lange KM, Moutsianas L, Lee JC, Lamb CA, Luo Y et al.

    Nature genetics 2017;49;2;256-261

  • Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

    Luo Y, de Lange KM, Jostins L, Moutsianas L, Randall J et al.

    Nature genetics 2017;49;2;186-192

  • Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

    Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R et al.

    Nature genetics 2015;47;9;979-986

  • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

    Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM et al.

    Nature genetics 2013;45;6;670-5

  • Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

    Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L et al.

    Nature genetics 2012;44;10;1137-41

  • Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

    Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS et al.

    Nature genetics 2011;43;4;329-32

  • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M et al.

    Nature genetics 2011;43;3;246-52

  • Synthetic associations are unlikely to account for many common disease genome-wide association signals.

    Anderson CA, Soranzo N, Zeggini E and Barrett JC

    PLoS biology 2011;9;1;e1000580

  • Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.

    Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J et al.

    Nature genetics 2011;43;1;51-4

  • Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

    Anderson CA, Pettersson FH, Barrett JC, Zhuang JJ, Ragoussis J et al.

    American journal of human genetics 2008;83;1;112-9

  • Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.

    Walker GJ, Harrison JW, Heap GA, Voskuil MD, Andersen V et al.

    JAMA 2019;321;8;773-785

  • Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System.

    Goode EC, Clark AB, Mells GM, Srivastava B, Spiess K et al.

    Hepatology (Baltimore, Md.) 2018

  • Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

    Darlay R, Ayers KL, Mells GF, Hall LS, Liu JZ et al.

    PLoS genetics 2018;14;12;e1007833

  • Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism.

    Cangul H, Liao XH, Schoenmakers E, Kero J, Barone S et al.

    JCI insight 2018;3;20

  • Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia.

    Petrova VN, Muir L, McKay PF, Vassiliou GS, Smith KGC et al.

    Frontiers in immunology 2018;9;1784

  • Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

    Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F et al.

    Gut 2017

  • Fine-mapping inflammatory bowel disease loci to single-variant resolution.

    Huang H, Fang M, Jostins L, Umićević Mirkov M, Boucher G et al.

    Nature 2017;547;7662;173-178

  • Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

    Luo Y, de Lange KM, Jostins L, Moutsianas L, Randall J et al.

    Nature genetics 2017;49;2;186-192

  • Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

    Lee JC, Biasci D, Roberts R, Gearry RB, Mansfield JC et al.

    Nature genetics 2017;49;2;262-268

  • Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

    de Lange KM, Moutsianas L, Lee JC, Lamb CA, Luo Y et al.

    Nature genetics 2017;49;2;256-261

  • A reference panel of 64,976 haplotypes for genotype imputation.

    McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR et al.

    Nature genetics 2016;48;10;1279-83

  • Comprehensive screening of eight known causative genes in congenital hypothyroidism with gland-in-situ.

    Nicholas AK, Serra EG, Cangul H, Alyaarubi S, Ullah I et al.

    The Journal of clinical endocrinology and metabolism 2016;jc20161879

  • Class II HLA interactions modulate genetic risk for multiple sclerosis.

    Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK et al.

    Nature genetics 2015;47;10;1107-13

  • Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

    Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R et al.

    Nature genetics 2015;47;9;979-986

  • Genetics in PSC: what do the "risk genes" teach us?

    Folseraas T, Liaskou E, Anderson CA and Karlsen TH

    Clinical reviews in allergy & immunology 2015;48;2-3;154-64

  • Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease.

    Raine T, Liu JZ, Anderson CA, Parkes M and Kaser A

    Gut 2015;64;2;250-9

  • High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

    Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L et al.

    Nature genetics 2015;47;2;172-9

  • Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations.

    Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L et al.

    American journal of human genetics 2014;94;6;915-23

  • Genetic studies of Crohn's disease: past, present and future.

    Liu JZ and Anderson CA

    Best practice & research. Clinical gastroenterology 2014;28;3;373-86

  • Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects.

    Williamson KA, Rainger J, Floyd JA, Ansari M, Meynert A et al.

    American journal of human genetics 2014;94;2;295-302

  • Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.

    Houldcroft CJ, Petrova V, Liu JZ, Frampton D, Anderson CA et al.

    PloS one 2014;9;10;e108384

  • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

    International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF et al.

    Nature genetics 2013;45;11;1353-60

  • Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.

    Lee JC, Espéli M, Anderson CA, Linterman MA, Pocock JM et al.

    Cell 2013;155;1;57-69

  • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

    Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM et al.

    Nature genetics 2013;45;6;670-5

  • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

    Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP et al.

    Nature 2012;491;7422;119-24

  • Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

    Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L et al.

    Nature genetics 2012;44;10;1137-41

  • optiCall: a robust genotype-calling algorithm for rare, low-frequency and common variants.

    Shah TS, Liu JZ, Floyd JA, Morris JA, Wirth N et al.

    Bioinformatics (Oxford, England) 2012;28;12;1598-603

  • Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

    Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS et al.

    Nature genetics 2011;43;4;329-32

  • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M et al.

    Nature genetics 2011;43;3;246-52

  • Synthetic associations are unlikely to account for many common disease genome-wide association signals.

    Anderson CA, Soranzo N, Zeggini E and Barrett JC

    PLoS biology 2011;9;1;e1000580

  • Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.

    Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J et al.

    Nature genetics 2011;43;1;51-4

  • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

    Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL et al.

    Nature genetics 2010;42;12;1118-25

  • Data quality control in genetic case-control association studies.

    Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP and Zondervan KT

    Nature protocols 2010;5;9;1564-73

  • Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

    Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P et al.

    Nature genetics 2010;42;5;436-40

  • Tryptophan depletion and formation of alpha-aminoadipic and gamma-glutamic semialdehydes in porcine burger patties with added phenolic-rich fruit extracts.

    Ganhão R, Morcuende D and Estévez M

    Journal of agricultural and food chemistry 2010;58;6;3541-8

  • Common variants at five new loci associated with early-onset inflammatory bowel disease.

    Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V et al.

    Nature genetics 2009;41;12;1335-40

  • Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

    UK IBD Genetics Consortium, Barrett JC, Lee JC, Lees CW, Prescott NJ et al.

    Nature genetics 2009;41;12;1330-4

  • Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

    Anderson CA, Massey DC, Barrett JC, Prescott NJ, Tremelling M et al.

    Gastroenterology 2009;136;2;523-9.e3

  • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

    Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH et al.

    Nature genetics 2008;40;8;955-62

  • Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

    Anderson CA, Pettersson FH, Barrett JC, Zhuang JJ, Ragoussis J et al.

    American journal of human genetics 2008;83;1;112-9

  • Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

    Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S et al.

    Nature genetics 2008;40;6;710-2

  • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

    Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA et al.

    Nature genetics 2007;39;7;830-2

Anderson, Carl
Carl's Timeline
2014

Appointed Director of Graduate Studies at the Sanger Institute

Promoted to Group Leader at the Sanger Institute

2009

Started at the Sanger Institute (CDF Group Leader)

2007

Started postdoctoral fellowship at the Wellcome Trust Centre of Human Genetics, Oxford

2006

Submitted PhD thesis (Genetic analysis of age-at-onset traits)

2005

Moved to Queenland Institute of Medical Research to continue PhD research

2003

Started PhD research at the University of Edinburgh (under supervision of Peter Visscher)

2001

Started MSc in Genetic Epidemiology at the University of Sheffield

1998

Started BSc in Biomedical Science at University of Sheffield

1980

Was born