Dr Chukwuma A. Agu | Senior Staff Scientist

This person is a member of Sanger Institute Alumni.

Agu, Chukwuma A.

I am a molecular/cell biologist specialising in human induced pluripotent stem cells, cellular reprogramming and differentiation.

My work in the past has centered on application of novel protein therapeutics and gene therapy for cancer. My current work involves the development of optimised methods for IPSC culture for widespread use in high throughput applications, including cellular reprogramming, differentiation and disease modelling.

Publications

  • Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.

    Agu CA, Soares FA, Alderton A, Patel M, Ansari R et al.

    Stem cell reports 2015;5;4;660-71

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.

    Agu CA, Soares FA, Alderton A, Patel M, Ansari R et al.

    Stem cell reports 2015;5;4;660-71

  • Toxin Kid uncouples DNA replication and cell division to enforce retention of plasmid R1 in Escherichia coli cells.

    Pimentel B, Nair R, Bermejo-Rodríguez C, Preston MA, Agu CA et al.

    Proceedings of the National Academy of Sciences of the United States of America 2014;111;7;2734-9

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • Bacteriophage-encoded toxins: the lambda-holin protein causes caspase-independent non-apoptotic cell death of eukaryotic cells.

    Agu CA, Klein R, Lengler J, Schilcher F, Gregor W et al.

    Cellular microbiology 2007;9;7;1753-65

  • The cytotoxic activity of the bacteriophage lambda-holin protein reduces tumour growth rates in mammary cancer cell xenograft models.

    Agu CA, Klein R, Schwab S, König-Schuster M, Kodajova P et al.

    The journal of gene medicine 2006;8;2;229-41

Agu, Chukwuma A.
Chukwuma's Timeline
2010

Joined the Wellcome Trust Sanger Institute

2007

Post doctoral fellow at the Hutchison MRC Cancer Unit, University of Cambridge, UK

2005

PhD in Natural Sciences Biology, University of Vienna, Austria

2000

MSc in Natural Sciences Biology, University of Vienna, Austria