About This Portal
The Wellcome Trust Sanger Institute generates, characterises, and uses a variety of reagents for mouse genetics research. It also aims to facilitate the distribution of these resources to the external scientific community. Here, you will find unified access to the different resources available from the Institute or its collaborators. The resources include: 129S7 and C57BL6/J bacterial artificial chromosomes (BACs), MICER gene targeting vectors, knock-out first conditional-ready gene targeting vectors, embryonic stem (ES) cells with gene targeted mutations or with retroviral gene trap insertions, mutant mouse lines, and phenotypic data generated from the Institute's primary screen.
Other Data Summary
The table below displays the number of unique genes with each individual product type produced at the Wellcome Trust Sanger Institute.
Phenotyping Raw Data Access
Viewing Our Data in Ensembl
Karp, Natasha A., Anne Segonds-Pichon, Anna-Karin B. Gerdin, Ramiro Ramírez-Solis, and Jacqueline K. White. "The fallacy of ratio correction to address confounding factors." Laboratory Animals 46, no. 3 (2012): 245-252. pmid
Gerdin, Anna-Karin, Natalia Igosheva, Laura-Anne Roberson, Ozama Ismail, Natasha Karp, Mark Sanderson, Emma Cambridge et al. "Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests." Physiology & behavior (2012). pmid
Nijnik, Anastasia, Simon Clare, Christine Hale, Jing Chen, Claire Raisen, Lynda Mottram, Mark Lucas et al. "The Role of Sphingosine-1-Phosphate Transporter Spns2 in Immune System Function." The Journal of Immunology 189, no. 1 (2012): 102-111. pmid
Karp, Natasha A., Lauren A. Baker, Anna-Karin B. Gerdin, Niels C. Adams, Ramiro Ramírez-Solis, and Jacqueline K. White. "Optimising experimental design for high-throughput phenotyping in mice: a case study." Mammalian genome 21, no. 9 (2010): 467-476. pmid
Morgan, Hugh, Tim Beck, Andrew Blake, Hilary Gates, Niels Adams, Guillaume Debouzy, Sophie Leblanc et al. "EuroPhenome: a repository for high-throughput mouse phenotyping data." Nucleic acids research 38, no. suppl 1 (2010): D577-D585. pmid
Ramírez‐Solis, Ramiro, Edward Ryder, Richard Houghton, Jacqueline K. White, and Joanna Bottomley. "Large‐scale mouse knockouts and phenotypes." Wiley Interdisciplinary Reviews: Systems Biology and Medicine (2012). pmid
Migdalska, Anna M., Louise van der Weyden, Ozama Ismail, Jacqueline K. White, Gabriela Sánchez-Andrade, Darren W. Logan, Mark J. Arends, and David J. Adams. "Modeling Partial Monosomy for Human Chromosome 21q11. 2-q21. 1 Reveals Haploinsufficient Genes Influencing Behavior and Fat Deposition." PloS one 7, no. 1 (2012): e29681. pmid
Bassett, JH Duncan, Apostolos Gogakos, Jacqueline K. White, Holly Evans, Richard M. Jacques, Anne H. van der Spek, Ramiro Ramirez-Solis et al. "Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength." PLoS Genetics 8, no. 8 (2012): e1002858. pmid
van der Weyden, Louise, Jacqueline K. White, David J. Adams, and Darren W. Logan. "The mouse genetics toolkit: revealing function and mechanism." Genome biology 12, no. 6 (2011): 224. pmid
Migdalska, Anna M., Louise van der Weyden, Ozama Ismail, Alistair G. Rust, Mamunur Rashid, Jacqueline K. White, Gabriela Sánchez-Andrade et al. "Generation of the Sotos syndrome deletion in mice." Mammalian Genome (2012): 1-9. pmid
Nijnik, Anastasia, Simon Clare, Christine Hale, Claire Raisen, Rebecca E. McIntyre, Kosuke Yusa, Aaron R. Everitt et al. "The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation." Blood 119, no. 6 (2012): 1370-1379. pmid
Ayadi, Abdel, Marie-Christine Birling, Joanna Bottomley, James Bussell, Helmut Fuchs, Martin Fray, Valérie Gailus-Durner et al. "Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project." Mammalian Genome (2012): 1-11. pmid
Funding for the generation and archiving of mouse lines by the Sanger Institute was provided by
- the Wellcome Trust (grant )
- the National Institutes of Health (KOMP; awards [UO1-HG004080]; [1-U42RR033192])
- the European Commission
- EUMODIC (contract [LSHG-CT-2006-037188])
- EMMAService (grant )
- Infrafrontier-I3 (grants ; )
- EUCOMMTools (grant )
Get in Touch
For enquiries about the data displayed in this portal (or requests for further information), please contact MGPEnquiries@sanger.ac.uk.
For enquiries about access to mouse lines, please contact firstname.lastname@example.org.
If you have any problems/comments with regards to this portal, or would like to request a new feature please send an email to email@example.com, we'd like to hear from you!