Dr Julian Sale

Associate Faculty

My research interests focus on the mechanisms of mutagenesis and epimutagenesis, specifically how these are driven by events occurring during DNA replication.

My research team has developed and exploited genetic models for studying the genetic control of the replication of DNA damage and secondary structures. More recently, we have been exploring how replication-associated mutagenic processes shape the evolution and function of the human genome.

My main research group has been based at the MRC Laboratory of Molecular Biology since 2003. I became an Associate Faculty member at the Sanger Institute in 2022 to work with fellow Associate Faculty members Jason Chin, Tom Ellis and Patrick Cai on genome synthesis.

I am also Francis Crick Lecturer in Pathology at Gonville & Caius College and Senior Executive Editor of Nucleic Acids Research.

My timeline

• Associate Faculty, Sanger Institute

• Senior Executive Editor, Nucleic Acids Research (OUP)

• Executive Editor, Nucleic Acids Research (OUP)

• Programme Leader, MRC Laboratory of Molecular Biology

• Programme Leader-Track, MRC Laboratory of Molecular Biology

• Teaching Fellowship in Pathology, Gonville & Caius College, Cambridge

• PhD

• MRC Clinician Scientist Fellowship

• Research Fellowship, Gonville & Caius College, Cambridge

• MRC Training Fellowship with Michael Neuberger, MRC Laboratory of Molecular Biology on the mechanisms of immunoglobulin gene somatic hypermutation

• Membership of Royal College of Physicians (UK)

• Junior hospital doctor