My research interest revolves around understanding the transcriptional regulation of resistance in Plasmodium falciparum. Emergence of resistance requires stringent transcriptional regulation, which in turn is dictated by various key molecular players. Deciphering the role of these molecules can open up more avenue for the development of malaria transmission blocking intervention strategies.
I completed my PhD at Indian Institute of Science Education and Research (IISER), Pune India and conducted my thesis work in the lab of Dr. Krishanpal Karmodiya. There I focussed on deciphering the role of epigenetic gene regulation in mediating stress responses and artemisinin-resistance in the malaria parasite. For my post-doctoral research I intend to leverage my expertise in epigenetic and genome editing to more deeply understand the process of transcriptional regulation in drug resistance in Plasmodium falciparum. Identifying new antimalarial candidates and studying their cellular targets, underlying resistance mechanism and measuring fitness cost associated with resistance can help us in controlling and eradicating malaria globally.
Connect with me on Twitter
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The Meléndez Lab is hiring. Grant funding for multiple positions. To apply please contact alicia.melendez@qc.cuny.edu #celegans #autophagy #germline
Excited to share that our latest work on Plasmodium proteasome inhibitors is finally out in @CellChemBiol! Huge thanks especially to our many collaborators without whom this work would not have been possible https://twitter.com/cellchembiol/status/1638918660978012162
Online now! Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome http://dlvr.it/SlMPnr #chembiol
Happening today at 6pm IST.
Considering you have had a lot of requests, we will be doing a YouTube live, the link of which will be shared 30 min prior to the session. Stay tuned!
@PostdocPhd @PhDVoice @VoicesofIndAcad
