Dr Uzma Basit Khan

Senior Computer Biologist


This person is a member of Sanger Institute Alumni.

I have worked at the Wellcome Sanger Institute for about 5 years (Feb 2020 till June 2024). I am excited to announce that I have accepted a position as a postdoctoral fellow in microbial informatics at the University of Oxford (Jul 2024 till Jul 2026).

For the past five years at the Sanger Institute, I've delved into the genomic analysis of global Group B Streptococcus (GBS), uncovering antibiotic resistance mechanisms. As a bioinformatics trainer, I've also collaborated with JUNO partners, contributing to impactful scientific publications.

From Genomes to Global Impact: My Sanger Experience

I have worked at the Sanger Institute as a Senior Computational Biologist in the JUNO project from Feb 2020 to Jun 2024. My research primarily focused on studying the evolution, epidemiology, and antimicrobial resistance in disease-causing and colonizing GBS strains from various countries. I developed the first comprehensive GBS database and led the analysis of approximately 27,000 global GBS genomes to address key questions in GBS disease and vaccine development.

I have a passion for teaching and sharing skills and knowledge with others. During my tenure at the Sanger Institute, I worked as a bioinformatics trainer and conducted workshops in Colombia, Turkey, and Pakistan. Additionally, I supervised various research projects of JUNO partners, assisting them with workflow analysis and manuscript preparation.

I have had the honor of being invited as a plenary speaker at international GBS and pediatric infection conferences to share my research findings with the wider community.

I completed my PhD in Medicine from Cardiff University in 2020, where I conducted intensive genomic interrogation of whole genome sequencing (WGS) and systematic phenotypic antimicrobial resistance profiling for all invasive and non-invasive GBS infections in adults in the UK, Brazil, and Australia between 2014 and 2015. Furthermore, I conducted research on capsular switching mechanisms, phylogenetic relationships among strains belonging to the five main GBS lineages, mobile elements carrying antimicrobial resistance genes, and performed a pangenome-wide association study to identify lineage-specific genes potentially suitable as vaccine candidates.

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