Dr Stephen Doyle | Postdoctoral Fellow

Doyle, Stephen

I joined the Parasite Genomics group in 2015 as a Postdoctoral Fellow to work on the population genomics of drug selection in two important veterinary parasites, Haemonchus contortus and Teladorsagia circumcincta. This work is part of a larger BBSRC-funded project to utilise genomic resources to develop novel interventions to control endemic gastrointestinal parasites of small ruminants.

Publications

  • A Genome Resequencing-Based Genetic Map Reveals the Recombination Landscape of an Outbred Parasitic Nematode in the Presence of Polyploidy and Polyandry.

    Doyle SR, Laing R, Bartley DJ, Britton C, Chaudhry U et al.

    Genome biology and evolution 2018;10;2;396-409

  • Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.

    Doyle SR, Bourguinat C, Nana-Djeunga HC, Kengne-Ouafo JA, Pion SDS et al.

    PLoS neglected tropical diseases 2017;11;7;e0005816

  • Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta.

    Choi YJ, Bisset SA, Doyle SR, Hallsworth-Pepin K, Martin J et al.

    PLoS genetics 2017;13;6;e1006857

  • Significant heterogeneity in Wolbachia copy number within and between populations of Onchocerca volvulus.

    Armoo S, Doyle SR, Osei-Atweneboana MY and Grant WN

    Parasites & vectors 2017;10;1;188

  • The genome of Onchocerca volvulus, agent of river blindness.

    Cotton JA, Bennuru S, Grote A, Harsha B, Tracey A et al.

    Nature microbiology 2016;2;16216

  • Discrimination between Onchocerca volvulus and O. ochengi filarial larvae in Simulium damnosum (s.l.) and their distribution throughout central Ghana using a versatile high-resolution speciation assay.

    Doyle SR, Armoo S, Renz A, Taylor MJ, Osei-Atweneboana MY and Grant WN

    Parasites & vectors 2016;9;1;536

  • The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus.

    Rezansoff AM, Laing R, Martinelli A, Stasiuk S, Redman E et al.

    International journal for parasitology 2019

  • Screening the Saccharomyces cerevisiae non-essential gene deletion library reveals diverse mechanisms of action for antifungal plant defensins.

    Parisi K, Doyle SR, Lee E, Lowe RG, van der Weerden NL et al.

    Antimicrobial agents and chemotherapy 2019

  • Refugia and anthelmintic resistance: Concepts and challenges.

    Hodgkinson JE, Kaplan RM, Kenyon F, Morgan ER, Park AW et al.

    International journal for parasitology. Drugs and drug resistance 2019;10;51-57

  • Genome-wide Approaches to Investigate Anthelmintic Resistance.

    Doyle SR and Cotton JA

    Trends in parasitology 2019;35;4;289-301

  • Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus.

    Doyle SR, Illingworth CJR, Laing R, Bartley DJ, Redman E et al.

    BMC genomics 2019;20;1;218

  • Comparative genomics of the major parasitic worms.

    International Helminth Genomes Consortium

    Nature genetics 2019;51;1;163-174

  • Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing.

    Doyle SR, Sankaranarayanan G, Allan F, Berger D, Jimenez Castro PD et al.

    Frontiers in genetics 2019;10;826

  • Biology and genome of a newly discovered sibling species of Caenorhabditis elegans.

    Kanzaki N, Tsai IJ, Tanaka R, Hunt VL, Liu D et al.

    Nature communications 2018;9;1;3216

  • A Genome Resequencing-Based Genetic Map Reveals the Recombination Landscape of an Outbred Parasitic Nematode in the Presence of Polyploidy and Polyandry.

    Doyle SR, Laing R, Bartley DJ, Britton C, Chaudhry U et al.

    Genome biology and evolution 2018;10;2;396-409

  • PLAG1 deficiency impairs spermatogenesis and sperm motility in mice.

    Juma AR, Grommen SVH, O'Bryan MK, O'Connor AE, Merriner DJ et al.

    Scientific reports 2017;7;1;5317

  • Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.

    Doyle SR, Bourguinat C, Nana-Djeunga HC, Kengne-Ouafo JA, Pion SDS et al.

    PLoS neglected tropical diseases 2017;11;7;e0005816

  • Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta.

    Choi YJ, Bisset SA, Doyle SR, Hallsworth-Pepin K, Martin J et al.

    PLoS genetics 2017;13;6;e1006857

  • Significant heterogeneity in Wolbachia copy number within and between populations of Onchocerca volvulus.

    Armoo S, Doyle SR, Osei-Atweneboana MY and Grant WN

    Parasites & vectors 2017;10;1;188

  • You Are What You Eat: A Genomic Analysis of the Gut Microbiome of Captive and Wild Octopus vulgaris Paralarvae and Their Zooplankton Prey.

    Roura Á, Doyle SR, Nande M and Strugnell JM

    Frontiers in physiology 2017;8;362

  • The genome of Onchocerca volvulus, agent of river blindness.

    Cotton JA, Bennuru S, Grote A, Harsha B, Tracey A et al.

    Nature microbiology 2016;2;16216

  • Discrimination between Onchocerca volvulus and O. ochengi filarial larvae in Simulium damnosum (s.l.) and their distribution throughout central Ghana using a versatile high-resolution speciation assay.

    Doyle SR, Armoo S, Renz A, Taylor MJ, Osei-Atweneboana MY and Grant WN

    Parasites & vectors 2016;9;1;536

  • Massively parallel sequencing of customised forensically informative SNP panels on the MiSeq.

    Mehta B, Daniel R, Phillips C, Doyle S, Elvidge G and McNevin D

    Electrophoresis 2016;37;21;2832-2840

  • MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing.

    Wong NC, Pope BJ, Candiloro IL, Korbie D, Trau M et al.

    BMC bioinformatics 2016;17;98

  • Locating and Activating Molecular 'Time Bombs': Induction of Mycolata Prophages.

    Dyson ZA, Brown TL, Farrar B, Doyle SR, Tucci J et al.

    PloS one 2016;11;8;e0159957

  • Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat.

    Wong NC, Pope BJ, Candiloro I, Korbie D, Trau M et al.

    GigaScience 2015;4;55

  • Low-coverage MiSeq next generation sequencing reveals the mitochondrial genome of the Eastern Rock Lobster, Sagmariasus verreauxi.

    Doyle SR, Griffith IS, Murphy NP and Strugnell JM

    Mitochondrial DNA 2015;26;6;844-5

  • Evidence of evolutionary constraints that influences the sequence composition and diversity of mitochondrial matrix targeting signals.

    Doyle SR, Kasinadhuni NR, Chan CK and Grant WN

    PloS one 2013;8;6;e67938

  • Enhanced annealing of mismatched oligonucleotides using a novel melting curve assay allows efficient in vitro discrimination and restriction of a single nucleotide polymorphism.

    Doyle SR, Chan CK and Grant WN

    BMC biotechnology 2011;11;83

  • Mitochondrial gene therapy: an evaluation of strategies for the treatment of mitochondrial DNA disorders.

    Doyle SR and Chan CK

    Human gene therapy 2008;19;12;1335-48

  • Differential intracellular distribution of DNA complexed with polyethylenimine (PEI) and PEI-polyarginine PTD influences exogenous gene expression within live COS-7 cells.

    Doyle SR and Chan CK

    Genetic vaccines and therapy 2007;5;11

Doyle, Stephen
Stephen's Timeline
2015

Joined the Parasite Genomics group, Wellcome Trust Sanger Institute

2012

Early Career Development Fellow, La Trobe University

2011

PhD, La Trobe University