GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
A1L2A0_DANRE ITPK1 ENSDARG00000070583 4 Not determined 3
B0S5R9_DANRE FGF7 ENSDARG00000087715 None Not determined 2
capzb CAPZB ENSDARG00000046004 None Not determined 4
dio1 DIO1 ENSDARG00000042112 None Not determined 1
fbxo15 FBXO15 ENSDARG00000016897 None Not determined 1
fgf7 FGF7 ENSDARG00000059387 None Not determined 2
foxe1 FOXE1 ENSDARG00000079266 2 Not determined 5
foxe3 FOXE1 ENSDARG00000062892 None Not determined 5
igfbp5a IGFBP5 ENSDARG00000039264 None Not determined 2
igfbp5b IGFBP5 ENSDARG00000025348 None Not determined 2
insra INSR ENSDARG00000011948 3 Normal 6
insrb INSR ENSDARG00000071524 3 Not determined 6
itpk1 ITPK1 ENSDARG00000013056 3 Not determined 3
maf MAF ENSDARG00000015890 None Not determined 8
MAF (1 of 2) MAF ENSDARG00000076520 1 Not determined 8
mbip MBIP ENSDARG00000019364 2 Normal 2
neto1 NETO1 ENSDARG00000068483 1 Not determined 2
neto1l NETO1 ENSDARG00000071596 3 Not determined 2
nfia NFIA ENSDARG00000062420 2 Not determined 6
NP_957396.1 PDE10A ENSDARG00000003449 4 Not determined 2
nr3c2 NR3C2 ENSDARG00000037025 1 Not determined 5
nrg1 NRG1 ENSDARG00000068458 1 Not determined 6
prdm11 PRDM11 ENSDARG00000074468 None Not determined 1
si:dkey-281i8.3 FGF7 ENSDARG00000078625 None Not determined 2
si:dkeyp-1d11.1 PDE8B ENSDARG00000063706 13 Not determined 5
vegfaa VEGFA ENSDARG00000045971 None Not determined 8
vegfab VEGFA ENSDARG00000034700 None Not determined 8
zgc:112165 LPCAT2 ENSDARG00000053010 2 Not determined 1
zgc:161973 FBXO15 ENSDARG00000029848 None Not determined 1

The following reported genes could not be linked automatically to a zebrafish gene:

  • AADAT
  • AADAT
  • ABO
  • ABO
  • CAPNS2
  • CAPNS2
  • GLIS3
  • GLIS3
  • LHX3
  • LHX3
  • LHX3
  • LOC440389
  • LOC440389
  • MIR1179
  • MIR1179
  • SASH1
  • SASH1
  • SOX9
  • SOX9
  • SOX9
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