GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
apoeb APOE ENSDARG00000040295 1 Not determined 42
cfh CFH ENSDARG00000075761 3 Not determined 12
cfhl1 CFH ENSDARG00000056771 2 Not determined 12
cfhl2 CFH ENSDARG00000056778 4 Not determined 12
cfhl3 CFH ENSDARG00000094661 None Not determined 12
cfhl4 CFH ENSDARG00000094496 None Not determined 12
dapk3 DAPK3 ENSDARG00000074447 1 Normal 1
fam84b FAM84B ENSDARG00000032859 None Not determined 2
gli2a GLI2 ENSDARG00000025641 8 Not determined 3
gli2b GLI2 ENSDARG00000020884 6 Not determined 3
gli3 GLI3 ENSDARG00000052131 7 Normal 2
hbl1 MBL2 ENSDARG00000068221 None Not determined 2
hbl2 MBL2 ENSDARG00000094681 1 Not determined 2
hbl3 MBL2 ENSDARG00000068220 1 Not determined 2
hbl4 MBL2 ENSDARG00000054202 None Not determined 2
htra1a HTRA1 ENSDARG00000032831 5 Normal 9
htra1b HTRA1 ENSDARG00000014907 4 Not determined 9
inhbb INHBB ENSDARG00000040777 1 Not determined 4
itgb1bp3 ITGB1BP3 ENSDARG00000067848 1 Not determined 1
LOC555897 TRPC4 ENSDARG00000070507 3 Not determined 2
LOC560512 PVRL2 ENSDARG00000077419 None Not determined 9
LOC560816 PVRL2 ENSDARG00000062831 None Not determined 9
mibp ITGB1BP3 ENSDARG00000094727 None Not determined 1
mibp2 ITGB1BP3 ENSDARG00000042931 None Not determined 1
NP_571768.1 ITGB1BP3 ENSDARG00000078945 None Not determined 1
pcf11 PCF11 ENSDARG00000044625 6 Not determined 2
postn POSTN ENSDARG00000061219 1 Not determined 1
pvrl2l PVRL2 ENSDARG00000063390 1 Not determined 9
pvrl4 PVRL2 ENSDARG00000094356 None Not determined 9
Q5RI69_DANRE CFH ENSDARG00000094134 None Not determined 12
rab30 RAB30 ENSDARG00000037884 None Not determined 2
si:ch211-141e20.2 PVRL2 ENSDARG00000093349 None Not determined 9
si:ch211-214p13.3 PVRL2 ENSDARG00000087403 1 Not determined 9
si:ch211-222f23.6 PVRL2 ENSDARG00000042880 1 Not determined 9
si:dkey-109i21.1 POSTN ENSDARG00000043806 4 Not determined 1
si:dkey-114d20.1 CFH ENSDARG00000092786 None Not determined 12
si:dkey-114d20.3 CFH ENSDARG00000091868 None Not determined 12
si:dkey-240h12.4 DAPK3 ENSDARG00000034210 4 Not determined 1
si:dkey-281i8.1 PVRL2 ENSDARG00000069936 None Not determined 9
si:dkey-78k11.2 CD46 ENSDARG00000095512 None Not determined 3
tomm40 TOMM40 ENSDARG00000092112 1 Not determined 23
tomm40l TOMM40 ENSDARG00000036721 None Not determined 23
trpc4 TRPC4 ENSDARG00000062183 4 Not determined 2
tyr TYR ENSDARG00000039077 None Not determined 9
zgc:110064 APOE ENSDARG00000086370 1 Not determined 42
zgc:110182 FAM84B ENSDARG00000040280 None Not determined 2
zgc:110775 CD46 ENSDARG00000056075 1 Not determined 3

The following reported genes could not be linked automatically to a zebrafish gene:

  • ARMS2
  • ARMS2
  • CD34
  • CD34
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