GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
adamtsl7 THSD4 ENSDARG00000055439 1 Not determined 3
B6E518_DANRE SEMA7A ENSDARG00000070442 5 Not determined 1
C7U131_DANRE PTPRD ENSDARG00000044635 3 Not determined 11
chrna5 CHRNA5 ENSDARG00000003420 3 Normal 13
cxcr7b CXCR7 ENSDARG00000058179 2 1 phenotype, 1 normal 1
CYYR1 CYYR1 ENSDARG00000087505 None Not determined 1
emx2 EMX2 ENSDARG00000039701 None Not determined 4
emx3 EMX2 ENSDARG00000020417 None Not determined 4
gpr126 GPR126 ENSDARG00000054137 1 Not determined 9
HTR4 HTR4 ENSDARG00000061940 1 Not determined 5
ide IDE ENSDARG00000075570 4 Not determined 2
ITPR1 (2 of 2) ITPR1 ENSDARG00000014655 10 Normal 2
lef1 LEF1 ENSDARG00000031894 4 Not determined 3
LOC100002026 PCDH8 ENSDARG00000042586 1 Not determined 2
LOC100333724 ITPR1 ENSDARG00000074149 8 Not determined 2
LOC559635 AGPHD1 ENSDARG00000077610 None Not determined 2
LOC562420 CALN1 ENSDARG00000088898 1 Not determined 1
pcdh8 PCDH8 ENSDARG00000006467 1 Not determined 2
ppap2b PPAP2B ENSDARG00000059933 None Not determined 4
PTPRD (2 of 2) PTPRD ENSDARG00000059452 6 Not determined 11
ptprdb PTPRD ENSDARG00000019945 12 Normal 11
sema7a SEMA7A ENSDARG00000078707 3 Not determined 1
SEMA7A (2 of 2) SEMA7A ENSDARG00000090776 None Not determined 1
sept9a SEPT9 ENSDARG00000020235 2 Not determined 2
sept9b SEPT9 ENSDARG00000041718 None Not determined 2
sez6l SEZ6L ENSDARG00000076028 5 Not determined 2
si:ch211-45c16.2 MAP3K13 ENSDARG00000009493 7 Not determined 1
si:ch73-362g18.2 CREB5 ENSDARG00000070536 None Not determined 4
si:dkey-247m21.3 HTR4 ENSDARG00000001906 3 Not determined 5
si:dkey-33c18.3 SPATA13 ENSDARG00000062837 2 Not determined 3
si:dkeyp-6a12.1 CALN1 ENSDARG00000069766 1 1 phenotype 1
si:dkeyp-74a11.11 CXCR7 ENSDARG00000062478 1 Not determined 1
srp72 SRP72 ENSDARG00000014139 3 Not determined 1
st8sia2 ST8SIA2 ENSDARG00000018788 2 Not determined 2
tbx5a TBX5 ENSDARG00000024894 None Not determined 10
tbx5b TBX5 ENSDARG00000092060 None Not determined 10
zgc:123181 PCDH8 ENSDARG00000095430 1 Not determined 2
zgc:158309 PPAP2B ENSDARG00000069940 7 Not determined 4
zgc:171550 AGPHD1 ENSDARG00000074341 2 Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • CBLN
  • DCDC2
  • GPR177
  • MGC16169
  • RARB
  • SERPINB8
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