GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
bfb CFB ENSDARG00000005616 3 Not determined 6
cfb CFB ENSDARG00000055278 4 Not determined 6
cfh CFH ENSDARG00000075761 3 Not determined 12
cfhl1 CFH ENSDARG00000056771 2 Not determined 12
cfhl2 CFH ENSDARG00000056778 4 Not determined 12
cfhl3 CFH ENSDARG00000094661 None Not determined 12
cfhl4 CFH ENSDARG00000094496 None Not determined 12
htra1a HTRA1 ENSDARG00000032831 5 Normal 9
htra1b HTRA1 ENSDARG00000014907 4 Not determined 9
Q5RI69_DANRE CFH ENSDARG00000094134 None Not determined 12
si:dkey-114d20.1 CFH ENSDARG00000092786 None Not determined 12
si:dkey-114d20.3 CFH ENSDARG00000091868 None Not determined 12
tnxb TNXB ENSDARG00000001760 5 Not determined 4
tomm40 TOMM40 ENSDARG00000092112 1 Not determined 23
tomm40l TOMM40 ENSDARG00000036721 None Not determined 23
zgc:158446 CFB ENSDARG00000090730 4 Not determined 6

The following reported genes could not be linked automatically to a zebrafish gene:

  • ARMS2
  • NOTCH4
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