GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
cdkal1 CDKAL1 ENSDARG00000022122 2 Not determined 23
fto FTO ENSDARG00000044216 3 Not determined 32
hmg20a HMG20A ENSDARG00000031198 None Not determined 3
LAMA1 LAMA1 ENSDARG00000056043 7 Not determined 2
LOC100002134 SLC30A8 ENSDARG00000054584 1 Not determined 16
LOC560642 SLC30A8 ENSDARG00000057629 None Not determined 16
NP_001165056.1 ADCY5 ENSDARG00000091342 1 Not determined 7
si:busm1-160c18.1 HLA-DQA2 ENSDARG00000053739 2 Not determined 17
si:busm1-194e12.11 HLA-DQA2 ENSDARG00000055441 1 Not determined 17
si:busm1-228j01.3 HLA-DQA2 ENSDARG00000086294 2 Not determined 17
si:busm1-228j01.5 HLA-DQA2 ENSDARG00000079593 3 Not determined 17
si:ch1073-403i13.1 HLA-DQA2 ENSDARG00000001832 None Not determined 17
si:ch73-211l2.3 HLA-DQA2 ENSDARG00000075932 1 Not determined 17
si:dkeyp-2h4.2 HLA-DQA2 ENSDARG00000031745 None Not determined 17
si:zfos-2070c2.1 HLA-DQA2 ENSDARG00000070206 None Not determined 17
si:zfos-367g9.1 HLA-DQA2 ENSDARG00000074816 1 Not determined 17
tcf7l2 TCF7L2 ENSDARG00000004415 5 Not determined 23
zgc:123107 HLA-DQA2 ENSDARG00000020286 None Not determined 17

The following reported genes could not be linked automatically to a zebrafish gene:

  • HHEX
  • IG2BP2
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