GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
adrb1 ADRB1 ENSDARG00000007490 None Not determined 3
adrb1 ADRB1 ENSDARG00000088851 None Not determined 3
atp2b1a ATP2B1 ENSDARG00000012684 2 Not determined 6
atp2b1b ATP2B1 ENSDARG00000007788 7 Not determined 6
cacnb2a CACNB2 ENSDARG00000079906 1 Not determined 8
cacnb2b CACNB2 ENSDARG00000055565 3 Not determined 8
chic2 CHIC2 ENSDARG00000022690 None Not determined 1
CSK (2 of 2) CSK ENSDARG00000067996 None Not determined 4
cyp17a1 CYP17A1 ENSDARG00000033566 3 Not determined 7
cyp17a2 CYP17A1 ENSDARG00000053966 None Not determined 7
EDN3 (1 of 2) EDN3 ENSDARG00000070925 None Not determined 3
fgf5 FGF5 ENSDARG00000035377 1 Not determined 4
fign FIGN ENSDARG00000008662 None Not determined 3
FIGN (2 of 2) FIGN ENSDARG00000091716 None Not determined 3
gnas GNAS ENSDARG00000043094 1 Not determined 3
gosr2 GOSR2 ENSDARG00000053070 1 Not determined 3
gucy1a3 GUCY1A3 ENSDARG00000013787 None Not determined 3
jag1a JAG1 ENSDARG00000030289 5 Normal 5
jag1b JAG1 ENSDARG00000013168 3 Not determined 5
LOC100002893 SLC39A8 ENSDARG00000087905 None Not determined 4
LOC100329326 MAP4 ENSDARG00000090938 None Not determined 1
LOC100334017 FES ENSDARG00000011449 4 Not determined 2
LOC100334188 TBX3 ENSDARG00000061509 None Not determined 8
LOC556502 ADM ENSDARG00000015263 1 Not determined 5
LOC570100 ADM ENSDARG00000069027 None Not determined 5
MAP4 (2 of 3) MAP4 ENSDARG00000075464 None Not determined 1
mecom MECOM ENSDARG00000060808 2 Not determined 7
mhc1uba HFE ENSDARG00000075963 None Not determined 20
mhc1ze HFE ENSDARG00000074765 None Not determined 20
mhc1zel HFE ENSDARG00000092162 1 Not determined 20
mov10a MOV10 ENSDARG00000015829 5 Not determined 2
mov10b.1 MOV10 ENSDARG00000061177 4 Not determined 2
mov10b.2 MOV10 ENSDARG00000056065 5 Normal 2
npr3 NPR3 ENSDARG00000035253 1 Not determined 7
NP_001071067.1 CSK ENSDARG00000070805 1 Not determined 4
NP_919406.1 HFE ENSDARG00000086877 1 Not determined 20
nt5c2a NT5C2 ENSDARG00000039399 3 Not determined 9
nt5c2b NT5C2 ENSDARG00000058231 2 Not determined 9
plekha7 PLEKHA7 ENSDARG00000060813 4 Not determined 3
plekha7b PLEKHA7 ENSDARG00000062220 9 Not determined 3
Q8MHB3_DANRE HFE ENSDARG00000076734 None Not determined 20
Q8MHB6_DANRE HFE ENSDARG00000088022 1 Not determined 20
si:ch211-101b18.1 ULK4 ENSDARG00000004176 8 Normal 3
si:ch211-119c24.3 EBF1 ENSDARG00000069196 1 Not determined 3
si:ch211-287j19.6 HFE ENSDARG00000001470 2 Not determined 20
si:ch211-51e8.2 EBF1 ENSDARG00000092635 1 Not determined 3
si:ch211-69e5.1 JAG1 ENSDARG00000079519 4 Not determined 5
si:ch73-213j4.4 HFE ENSDARG00000092731 None Not determined 20
si:ch73-34b5.3 GUCY1B3 ENSDARG00000086790 1 Not determined 2
si:ch73-38f1.1 EBF1 ENSDARG00000016116 2 Not determined 3
si:dkey-165i4.1 ATXN2 ENSDARG00000052897 5 Normal 10
si:dkey-211h10.1 EDN3 ENSDARG00000086669 1 Not determined 3
si:dkey-77a20.5 MAP4 ENSDARG00000068745 3 Not determined 1
si:dkeyp-100a1.4 MTHFR ENSDARG00000053087 None Not determined 4
si:rp71-17i16.5 PIK3CG ENSDARG00000037527 1 Not determined 5
SLC39A8 (1 of 2) SLC39A8 ENSDARG00000056757 1 Normal 4
SLC4A7 SLC4A7 ENSDARG00000073952 4 Not determined 4
tbx16 TBX3 ENSDARG00000007329 None Not determined 8
tbx3 TBX3 ENSDARG00000002216 5 Normal 8
tbx5a TBX5 ENSDARG00000024894 None Not determined 10
tbx5b TBX5 ENSDARG00000092060 None Not determined 10
tbx6 TBX3 ENSDARG00000006939 1 Not determined 8
zgc:136614 HFE ENSDARG00000069471 None Not determined 20
zgc:194508 C10orf107 ENSDARG00000086310 3 Not determined 2
zgc:64115 HFE ENSDARG00000036588 4 Not determined 20
zgc:77033 PIK3CG ENSDARG00000017757 2 Not determined 5
znf652 ZNF652 ENSDARG00000062302 1 Not determined 5

The following reported genes could not be linked automatically to a zebrafish gene:

  • ADAMTS-8
  • C5orf23
  • C5orf23
  • FLJ32810
  • NOV
  • NPPB
  • PLCE-1
  • TMEM133
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