GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
gak GAK ENSDARG00000094483 None Not determined 5
GAK (2 of 3) GAK ENSDARG00000090654 None Not determined 5
LOC100151158 GAK ENSDARG00000039384 None Not determined 5
LOC100333007 RAI1 ENSDARG00000076679 None Not determined 1
LOC560882 RAI1 ENSDARG00000086459 None Not determined 1
LRRK2 LRRK2 ENSDARG00000006169 6 Not determined 8
MAPT (2 of 2) MAPT ENSDARG00000087616 3 Not determined 11
mapta MAPT ENSDARG00000089314 2 Not determined 11
RAI1 (3 of 3) RAI1 ENSDARG00000090142 None Not determined 1
scarb2 SCARB2 ENSDARG00000086099 None Not determined 1
scarb2 SCARB2 ENSDARG00000086371 None Not determined 1
SCARB2 SCARB2 ENSDARG00000089844 None Not determined 1
si:dkey-19n13.4 GBA ENSDARG00000076058 1 Normal 3
slc41a1 SLC41A1 ENSDARG00000070214 1 Not determined 3
srebf1 SREBF1 ENSDARG00000067607 2 Not determined 1
syt4 SYT4 ENSDARG00000036505 None Not determined 1
usp25 USP25 ENSDARG00000012314 6 Not determined 2
zgc:154106 MCCC1 ENSDARG00000054046 None Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • LAMP3
  • RIT2
  • SNCA
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