GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
bin1 BIN1 ENSDARG00000058820 3 Not determined 6
cd2apl CD2AP ENSDARG00000015224 3 Not determined 1
clu CLU ENSDARG00000010434 None Not determined 5
LOC798358 MS4A4A ENSDARG00000091970 2 Not determined 1
LOC798679 MS4A4A ENSDARG00000095695 1 Not determined 1
ms4a17a.1 MS4A4A ENSDARG00000043798 None Not determined 1
ms4a17a.11 MS4A4A ENSDARG00000053561 None Not determined 1
ms4a17a.14 MS4A4A ENSDARG00000094809 None Not determined 1
ms4a17a.2 MS4A4A ENSDARG00000093546 4 Not determined 1
ms4a17a.4 MS4A4A ENSDARG00000014024 3 Not determined 1
ms4a17a.5 MS4A4A ENSDARG00000092204 2 Not determined 1
ms4a17a.6 MS4A4A ENSDARG00000007018 1 Not determined 1
ms4a17a.7 MS4A4A ENSDARG00000043796 None Not determined 1
ms4a17a.8 MS4A4A ENSDARG00000094854 1 Not determined 1
ms4a17a.9 MS4A4A ENSDARG00000043802 2 Not determined 1
ms4a17c.1 MS4A4A ENSDARG00000094643 None Not determined 1
ms4a17c.2 MS4A4A ENSDARG00000028659 None Not determined 1
picalm PICALM ENSDARG00000012866 1 Not determined 5
picalml PICALM ENSDARG00000014137 2 Not determined 5
si:ch73-132m10.4 MS4A4A ENSDARG00000054898 3 Not determined 1
si:dkey-174k12.3 MS4A4A ENSDARG00000092593 None Not determined 1
si:dkey-238j22.1 MS4A4A ENSDARG00000093512 None Not determined 1
si:dkey-78k11.2 CR1 ENSDARG00000095512 None Not determined 5
si:rp71-68g1.4 BIN1 ENSDARG00000042114 3 Not determined 6
zgc:110775 CR1 ENSDARG00000056075 1 Not determined 5
zgc:172302 ABCA7 ENSDARG00000074221 4 Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • CD33
  • EPHA1
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