Forster, Samuel
Sam's work combines microbiology, immunology and computational analysis to understand the functional role and community dynamics of the human microbiota in health and disease.
Understanding how our microbiota is acquired and the forces that cause it to change provides important insights into health and disease. Sam's research seeks to understand the relationship between host state, microbiota community and the susceptibility to diseases including inflammatory bowel disease and infections by opportunistic pathogens such as Clostridium difficile. His research is focused on:
- Metagenomic sequencing from large patient cohorts to understand microbiota community structure in health and disease and the factors that cause it to change
- Computational modelling and machine learning based approaches to understand microbiota community dynamics in health and dysbiotic disease
- Analysis of the diversity of host cellular and transcriptional responses using in-vitro and in-vivo models of human microbiota communities
This work ultimately seeks to provide novel bacteriotherapies and identify other therapeutic interventions to improve human health
Publications
-
Illuminating microbial diversity.
Nature reviews. Microbiology 2017;15;10;578
PUBMED: 28852214; DOI: 10.1038/nrmicro.2017.106
-
Transmission of the gut microbiota: spreading of health.
Nature reviews. Microbiology 2017;15;9;531-543
PUBMED: 28603278; PMC: 5837012; DOI: 10.1038/nrmicro.2017.50
-
Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
Nature 2016;533;7604;543-546
PUBMED: 27144353; PMC: 4890681; DOI: 10.1038/nature17645
-
HPMCD: the database of human microbial communities from metagenomic datasets and microbial reference genomes.
Nucleic acids research 2016;44;D1;D604-9
PUBMED: 26578596; PMC: 4702862; DOI: 10.1093/nar/gkv1216
-
Systematic discovery of probiotics.
Nature biotechnology 2015;33;1;47-9
PUBMED: 25574637; DOI: 10.1038/nbt.3111
-
Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1.
Nature immunology 2013;14;9;901-7
PUBMED: 23872679; DOI: 10.1038/ni.2667
-
RNA-eXpress annotates novel transcript features in RNA-seq data.
Bioinformatics (Oxford, England) 2013;29;6;810-2
PUBMED: 23396121; PMC: 3597146; DOI: 10.1093/bioinformatics/btt034
-
Interferome v2.0: an updated database of annotated interferon-regulated genes.
Nucleic acids research 2013;41;Database issue;D1040-6
PUBMED: 23203888; PMC: 3531205; DOI: 10.1093/nar/gks1215
-
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape.
Nature medicine 2012;18;8;1224-31
PUBMED: 22820642; DOI: 10.1038/nm.2830
-
Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance.
BMC biology 2018;16;1;104
PUBMED: 30236109; DOI: 10.1186/s12915-018-0569-5
-
Illuminating microbial diversity.
Nature reviews. Microbiology 2017;15;10;578
PUBMED: 28852214; DOI: 10.1038/nrmicro.2017.106
-
Transmission of the gut microbiota: spreading of health.
Nature reviews. Microbiology 2017;15;9;531-543
PUBMED: 28603278; PMC: 5837012; DOI: 10.1038/nrmicro.2017.50
-
Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
Nature 2016;533;7604;543-546
PUBMED: 27144353; PMC: 4890681; DOI: 10.1038/nature17645
-
HPMCD: the database of human microbial communities from metagenomic datasets and microbial reference genomes.
Nucleic acids research 2016;44;D1;D604-9
PUBMED: 26578596; PMC: 4702862; DOI: 10.1093/nar/gkv1216
-
MicroRNA as Type I Interferon-Regulated Transcripts and Modulators of the Innate Immune Response.
Frontiers in immunology 2015;6;334
PUBMED: 26217335; PMC: 4495342; DOI: 10.3389/fimmu.2015.00334
-
Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors.
Nucleic acids research 2015;43;2;1177-88
PUBMED: 25539920; PMC: 4333393; DOI: 10.1093/nar/gku1343
-
Systematic discovery of probiotics.
Nature biotechnology 2015;33;1;47-9
PUBMED: 25574637; DOI: 10.1038/nbt.3111
-
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage.
The EMBO journal 2013;32;20;2751-63
PUBMED: 24065129; PMC: 3801437; DOI: 10.1038/emboj.2013.203
-
Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1.
Nature immunology 2013;14;9;901-7
PUBMED: 23872679; DOI: 10.1038/ni.2667
-
Helicobacter pylori VacA suppresses Lactobacillus acidophilus-induced interferon beta signaling in macrophages via alterations in the endocytic pathway.
mBio 2013;4;3;e00609-12
PUBMED: 23760466; PMC: 3685213; DOI: 10.1128/mBio.00609-12
-
RNA-eXpress annotates novel transcript features in RNA-seq data.
Bioinformatics (Oxford, England) 2013;29;6;810-2
PUBMED: 23396121; PMC: 3597146; DOI: 10.1093/bioinformatics/btt034
-
Interferome v2.0: an updated database of annotated interferon-regulated genes.
Nucleic acids research 2013;41;Database issue;D1040-6
PUBMED: 23203888; PMC: 3531205; DOI: 10.1093/nar/gks1215
-
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape.
Nature medicine 2012;18;8;1224-31
PUBMED: 22820642; DOI: 10.1038/nm.2830
-
Interferon signatures in immune disorders and disease.
Immunology and cell biology 2012;90;5;520-7
PUBMED: 22491066; DOI: 10.1038/icb.2012.12
-
Systems biology of interferon responses.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011;31;1;5-11
PUBMED: 21226606; DOI: 10.1089/jir.2010.0126
-
Toll-like receptors as interferon-regulated genes and their role in disease.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011;31;1;13-25
PUBMED: 21198355; DOI: 10.1089/jir.2010.0095
-
INTERFEROME: the database of interferon regulated genes.
Nucleic acids research 2009;37;Database issue;D852-7
PUBMED: 18996892; PMC: 2686605; DOI: 10.1093/nar/gkn732