Alex Cagan investigates evolutionary processes in somatic tissue. His research focuses on characterising mutation and selection in healthy tissues and how this relates to cancer and ageing.
Evolution is often considered to be an almost imperceptibly slow process. However, the cells that compose our own bodies are constantly acquiring mutations. Some of these mutations may influence cellular phenotypes, such as growth, resulting in clonal expansions. Over time the body may become a patchwork of clones. These processes may have profound implications for cancer progression and ageing. Due to technical limitations this evolutionary landscape has remained almost totally unexplored. I work with laser capture microdissection and genome sequencing to describe and understand processes of somatic evolution. I seek to adapt methods from comparative evolutionary genomics to gain new insights into evolution within the body.
Natural Selection in the Great Apes.
Molecular biology and evolution 2016;33;12;3268-3283
Great ape genetic diversity and population history.
Identification of genomic variants putatively targeted by selection during dog domestication.
BMC evolutionary biology 2016;16;10
Genetic influences on brain gene expression in rats selected for tameness and aggression.
Evidence of long-term gene flow and selection during domestication from analyses of Eurasian wild and domestic pig genomes.
Nature genetics 2015;47;10;1141-8