Selected

• Decoding human fetal liver haematopoiesis.

  Popescu DM, Botting RA, Stephenson E, Green K, Webb S, Jardine L, Calderbank EF, Polanski K, Goh I, Efremova M et al.

  Nature 2019;574;7778;365-371

  PUBMED: 31597962; PMC: 6861135; DOI: 10.1038/s41586-019-1652-y

• The genetic changes of Wilms tumour.

  Treger TD, Chowdhury T, Pritchard-Jones K and Behjati S

  Nature reviews. Nephrology 2019;15;4;240-251

  PUBMED: 30705419; DOI: 10.1038/s41581-019-0112-0

• Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.

  Steele CD, Tarabichi M, Oukrif D, Webster AP, Ye H, Fittall M, Lombard P, Martincorena I, Tarpey PS, Collord G et al.

  Cancer cell 2019;35;3;441-456.e8

  PUBMED: 30889380; PMC: 6428691; DOI: 10.1016/j.ccell.2019.02.002

• Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.

  Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ and Cleveland DW

  Nature genetics 2019;51;4;705-715

  PUBMED: 30833795; PMC: 6441390; DOI: 10.1038/s41588-019-0360-8

• A Comparison Between Full-COLD PCR/HRM and PCR Sequencing for Detection of Mutations in Exon 9 of PIK3CA in Breast Cancer Patients.

  Ghalamkari S, Khosravian F, Mianesaz H, Kazemi M, Behjati M, Hakimian SM and Salehi M

  Applied biochemistry and biotechnology 2019;187;3;975-983

  PUBMED: 30109561; DOI: 10.1007/s12010-018-2859-3

• An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.

  Collord G, Tarpey P, Kurbatova N, Martincorena I, Moran S, Castro M, Nagy T, Bignell G, Maura F, Young MD et al.

  Scientific reports 2018;8;1;13537

  PUBMED: 30202034; PMC: 6131140; DOI: 10.1038/s41598-018-31659-0

• Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.

  Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A, Roberts ND, Hajjar S, Layeghifard M, Novokmet A, Kowalski PE et al.

  Science (New York, N.Y.) 2018;361;6405

  PUBMED: 30166462; PMC: 6176908; DOI: 10.1126/science.aam8419

• Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.

  Young MD, Mitchell TJ, Vieira Braga FA, Tran MGB, Stewart BJ, Ferdinand JR, Collord G, Botting RA, Popescu DM, Loudon KW et al.

  Science (New York, N.Y.) 2018;361;6402;594-599

  PUBMED: 30093597; PMC: 6104812; DOI: 10.1126/science.aat1699

• Prediction of acute myeloid leukaemia risk in healthy individuals.

  Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y et al.

  Nature 2018;559;7714;400-404

  PUBMED: 29988082; PMC: 6485381; DOI: 10.1038/s41586-018-0317-6

• Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

  Wegert J, Vokuhl C, Collord G, Del Castillo Velasco-Herrera M, Farndon SJ, Guzzo C, Jorgensen M, Anderson J, Slater O, Duncan C et al.

  Nature communications 2018;9;1;2378

  PUBMED: 29915264; PMC: 6006309; DOI: 10.1038/s41467-018-04650-6

• Recurrent rearrangements of FOS and FOSB define osteoblastoma.

  Fittall MW, Mifsud W, Pillay N, Ye H, Strobl AC, Verfaillie A, Demeulemeester J, Zhang L, Berisha F, Tarabichi M et al.

  Nature communications 2018;9;1;2150

  PUBMED: 29858576; PMC: 5984627; DOI: 10.1038/s41467-018-04530-z

• Intra-tumour diversification in colorectal cancer at the single-cell level.

  Roerink SF, Sasaki N, Lee-Six H, Young MD, Alexandrov LB, Behjati S, Mitchell TJ, Grossmann S, Lightfoot H, Egan DA et al.

  Nature 2018;556;7702;457-462

  PUBMED: 29643510; DOI: 10.1038/s41586-018-0024-3

• Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.

  Collord G, Martincorena I, Young MD, Foroni L, Bolli N, Stratton MR, Vassiliou GS, Campbell PJ and Behjati S

  British journal of haematology 2018;184;4;676-679

  PUBMED: 29602208; PMC: 6766952; DOI: 10.1111/bjh.15155

• Mapping human development at single-cell resolution.

  Behjati S, Lindsay S, Teichmann SA and Haniffa M

  Development (Cambridge, England) 2018;145;3

  PUBMED: 29439135; DOI: 10.1242/dev.152561

• Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

  Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, de Ligt J, Behjati S, Grolleman JE, van Wezel T et al.

  Science (New York, N.Y.) 2017;358;6360;234-238

  PUBMED: 28912133; PMC: 6038908; DOI: 10.1126/science.aao3130

• The driver landscape of sporadic chordoma.

  Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB, Farndon SJ, Guzzo C, Hardy C, Latimer C, Butler AP et al.

  Nature communications 2017;8;1;890

  PUBMED: 29026114; PMC: 5638846; DOI: 10.1038/s41467-017-01026-0

• How to use… lymph node biopsy in paediatrics.

  Farndon S, Behjati S, Jonas N and Messahel B

  Archives of disease in childhood. Education and practice edition 2017;102;5;244-248

  PUBMED: 28468821; DOI: 10.1136/archdischild-2015-309634

• Genetics: Taking single-cell transcriptomics to the bedside.

  Behjati S and Haniffa M

  Nature reviews. Clinical oncology 2017;14;10;590-592

  PUBMED: 28762386; DOI: 10.1038/nrclinonc.2017.117

• Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

  Behjati S, Tarpey PS, Haase K, Ye H, Young MD, Alexandrov LB, Farndon SJ, Collord G, Wedge DC, Martincorena I et al.

  Nature communications 2017;8;15936

  PUBMED: 28643781; PMC: 5490007; DOI: 10.1038/ncomms15936

• Molecular diagnoses of century-old childhood tumours.

  Virasami A, Farndon SJ, McDermott U, Sebire N and Behjati S

  The Lancet. Oncology 2017;18;5;e237

  PUBMED: 28495283; DOI: 10.1016/S1470-2045(17)30226-7

• Accurate Breakpoint Mapping in Apparently Balanced Translocation Families with Discordant Phenotypes Using Whole Genome Mate-Pair Sequencing.

  Aristidou C, Koufaris C, Theodosiou A, Bak M, Mehrjouy MM, Behjati F, Tanteles G, Christophidou-Anastasiadou V, Tommerup N and Sismani C

  PloS one 2017;12;1;e0169935

  PUBMED: 28072833; PMC: 5225008; DOI: 10.1371/journal.pone.0169935

• Retracing embryological fate.

  Behjati S

  Science (New York, N.Y.) 2016;354;6316;1109

  PUBMED: 27934728; DOI: 10.1126/science.aal2189

• Mutational signatures of ionizing radiation in second malignancies.

  Behjati S, Gundem G, Wedge DC, Roberts ND, Tarpey PS, Cooke SL, Van Loo P, Alexandrov LB, Ramakrishna M, Davies H et al.

  Nature communications 2016;7;12605

  PUBMED: 27615322; PMC: 5027243; DOI: 10.1038/ncomms12605

• Mutation Screening of BRCA Genes in 10 Iranian Males with Breast Cancer.

  Zorrieh Zahra A, Kadkhoda S, Behjati F, Aghakhani Moghaddam F, Badiei A, Sirati F, Afshin Alavi H, Atri M, Omranipour R and Keyhani E

  International journal of molecular and cellular medicine 2016;5;2;114-22

  PUBMED: 27478808; PMC: 4947216

• Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

  Ju YS, Tubio JM, Mifsud W, Fu B, Davies HR, Ramakrishna M, Li Y, Yates L, Gundem G, Tarpey PS et al.

  Genome research 2015;25;6;814-24

  PUBMED: 25963125; PMC: 4448678; DOI: 10.1101/gr.190470.115

• Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics.

  Presneau N, Baumhoer D, Behjati S, Pillay N, Tarpey P, Campbell PJ, Jundt G, Hamoudi R, Wedge DC, Loo PV et al.

  The journal of pathology. Clinical research 2015;1;2;113-23

  PUBMED: 27499898; PMC: 4858131; DOI: 10.1002/cjp2.13

• Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

  Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S et al.

  Nature genetics 2015;47;3;257-62

  PUBMED: 25642631; DOI: 10.1038/ng.3202

• High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.

  Linnemann C, van Buuren MM, Bies L, Verdegaal EM, Schotte R, Calis JJ, Behjati S, Velds A, Hilkmann H, Atmioui DE et al.

  Nature medicine 2015;21;1;81-5

  PUBMED: 25531942; DOI: 10.1038/nm.3773

• Dysfunction of phospholipase Cγ in immune disorders and cancer.

  Koss H, Bunney TD, Behjati S and Katan M

  Trends in biochemical sciences 2014;39;12;603-11

  PUBMED: 25456276; DOI: 10.1016/j.tibs.2014.09.004

• Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.

  Ju YS, Alexandrov LB, Gerstung M, Martincorena I, Nik-Zainal S, Ramakrishna M, Davies HR, Papaemmanuil E, Gundem G, Shlien A et al.

  eLife 2014;3

  PUBMED: 25271376; PMC: 4371858; DOI: 10.7554/eLife.02935

• Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

  Tubio JMC, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K et al.

  Science (New York, N.Y.) 2014;345;6196;1251343

  PUBMED: 25082706; PMC: 4380235; DOI: 10.1126/science.1251343

• Genome sequencing of normal cells reveals developmental lineages and mutational processes.

  Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC, Tamuri AU, Martincorena I, Petljak M, Alexandrov LB, Gundem G et al.

  Nature 2014;513;7518;422-425

  PUBMED: 25043003; PMC: 4227286; DOI: 10.1038/nature13448

• Processed pseudogenes acquired somatically during cancer development.

  Cooke SL, Shlien A, Marshall J, Pipinikas CP, Martincorena I, Tubio JM, Li Y, Menzies A, Mudie L, Ramakrishna M et al.

  Nature communications 2014;5;3644

  PUBMED: 24714652; PMC: 3996531; DOI: 10.1038/ncomms4644

• Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

  Behjati S, Tarpey PS, Sheldon H, Martincorena I, Van Loo P, Gundem G, Wedge DC, Ramakrishna M, Cooke SL, Pillay N et al.

  Nature genetics 2014;46;4;376-379

  PUBMED: 24633157; PMC: 4032873; DOI: 10.1038/ng.2921

• Wiping versus suction to clear neonatal airways at birth.

  Behjati S

  Lancet (London, England) 2014;383;9918;695

  PUBMED: 24560056; DOI: 10.1016/S0140-6736(14)60257-9

• A pathogenic mosaic TP53 mutation in two germ layers detected by next generation sequencing.

  Behjati S, Maschietto M, Williams RD, Side L, Hubank M, West R, Pearson K, Sebire N, Tarpey P, Futreal A et al.

  PloS one 2014;9;5;e96531

  PUBMED: 24810334; PMC: 4014518; DOI: 10.1371/journal.pone.0096531

• What is next generation sequencing?

  Behjati S and Tarpey PS

  Archives of disease in childhood. Education and practice edition 2013;98;6;236-8

  PUBMED: 23986538; PMC: 3841808; DOI: 10.1136/archdischild-2013-304340

• Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

  Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P, Wedge DC, Cooke SL, Gundem G, Davies H et al.

  Nature genetics 2013;45;12;1479-82

  PUBMED: 24162739; PMC: 3839851; DOI: 10.1038/ng.2814

• Signatures of mutational processes in human cancer.

  Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale AL et al.

  Nature 2013;500;7463;415-21

  PUBMED: 23945592; PMC: 3776390; DOI: 10.1038/nature12477

• Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma.

  Tarpey PS, Behjati S, Cooke SL, Van Loo P, Wedge DC, Pillay N, Marshall J, O'Meara S, Davies H, Nik-Zainal S et al.

  Nature genetics 2013;45;8;923-6

  PUBMED: 23770606; PMC: 3743157; DOI: 10.1038/ng.2668

2019

• Decoding human fetal liver haematopoiesis.

  Popescu DM, Botting RA, Stephenson E, Green K, Webb S, Jardine L, Calderbank EF, Polanski K, Goh I, Efremova M et al.

  Nature 2019;574;7778;365-371

  PUBMED: 31597962; PMC: 6861135; DOI: 10.1038/s41586-019-1652-y

• Spatiotemporal immune zonation of the human kidney.

  Stewart BJ, Ferdinand JR, Young MD, Mitchell TJ, Loudon KW, Riding AM, Richoz N, Frazer GL, Staniforth JUL, Vieira Braga FA et al.

  Science (New York, N.Y.) 2019;365;6460;1461-1466

  PUBMED: 31604275; PMC: 7343525; DOI: 10.1126/science.aat5031

• The genetic changes of Wilms tumour.

  Treger TD, Chowdhury T, Pritchard-Jones K and Behjati S

  Nature reviews. Nephrology 2019;15;4;240-251

  PUBMED: 30705419; DOI: 10.1038/s41581-019-0112-0

• Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.

  Steele CD, Tarabichi M, Oukrif D, Webster AP, Ye H, Fittall M, Lombard P, Martincorena I, Tarpey PS, Collord G et al.

  Cancer cell 2019;35;3;441-456.e8

  PUBMED: 30889380; PMC: 6428691; DOI: 10.1016/j.ccell.2019.02.002

• Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.

  Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ and Cleveland DW

  Nature genetics 2019;51;4;705-715

  PUBMED: 30833795; PMC: 6441390; DOI: 10.1038/s41588-019-0360-8

• A Comparison Between Full-COLD PCR/HRM and PCR Sequencing for Detection of Mutations in Exon 9 of PIK3CA in Breast Cancer Patients.

  Ghalamkari S, Khosravian F, Mianesaz H, Kazemi M, Behjati M, Hakimian SM and Salehi M

  Applied biochemistry and biotechnology 2019;187;3;975-983

  PUBMED: 30109561; DOI: 10.1007/s12010-018-2859-3

2018

• An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.

  Collord G, Tarpey P, Kurbatova N, Martincorena I, Moran S, Castro M, Nagy T, Bignell G, Maura F, Young MD et al.

  Scientific reports 2018;8;1;13537

  PUBMED: 30202034; PMC: 6131140; DOI: 10.1038/s41598-018-31659-0

• Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.

  Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A, Roberts ND, Hajjar S, Layeghifard M, Novokmet A, Kowalski PE et al.

  Science (New York, N.Y.) 2018;361;6405

  PUBMED: 30166462; PMC: 6176908; DOI: 10.1126/science.aam8419

• Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.

  Young MD, Mitchell TJ, Vieira Braga FA, Tran MGB, Stewart BJ, Ferdinand JR, Collord G, Botting RA, Popescu DM, Loudon KW et al.

  Science (New York, N.Y.) 2018;361;6402;594-599

  PUBMED: 30093597; PMC: 6104812; DOI: 10.1126/science.aat1699

• Prediction of acute myeloid leukaemia risk in healthy individuals.

  Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y et al.

  Nature 2018;559;7714;400-404

  PUBMED: 29988082; PMC: 6485381; DOI: 10.1038/s41586-018-0317-6

• Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

  Wegert J, Vokuhl C, Collord G, Del Castillo Velasco-Herrera M, Farndon SJ, Guzzo C, Jorgensen M, Anderson J, Slater O, Duncan C et al.

  Nature communications 2018;9;1;2378

  PUBMED: 29915264; PMC: 6006309; DOI: 10.1038/s41467-018-04650-6

• Recurrent rearrangements of FOS and FOSB define osteoblastoma.

  Fittall MW, Mifsud W, Pillay N, Ye H, Strobl AC, Verfaillie A, Demeulemeester J, Zhang L, Berisha F, Tarabichi M et al.

  Nature communications 2018;9;1;2150

  PUBMED: 29858576; PMC: 5984627; DOI: 10.1038/s41467-018-04530-z

• Intra-tumour diversification in colorectal cancer at the single-cell level.

  Roerink SF, Sasaki N, Lee-Six H, Young MD, Alexandrov LB, Behjati S, Mitchell TJ, Grossmann S, Lightfoot H, Egan DA et al.

  Nature 2018;556;7702;457-462

  PUBMED: 29643510; DOI: 10.1038/s41586-018-0024-3

• Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.

  Collord G, Martincorena I, Young MD, Foroni L, Bolli N, Stratton MR, Vassiliou GS, Campbell PJ and Behjati S

  British journal of haematology 2018;184;4;676-679

  PUBMED: 29602208; PMC: 6766952; DOI: 10.1111/bjh.15155

• Mapping human development at single-cell resolution.

  Behjati S, Lindsay S, Teichmann SA and Haniffa M

  Development (Cambridge, England) 2018;145;3

  PUBMED: 29439135; DOI: 10.1242/dev.152561

2017

• Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

  Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, de Ligt J, Behjati S, Grolleman JE, van Wezel T et al.

  Science (New York, N.Y.) 2017;358;6360;234-238

  PUBMED: 28912133; PMC: 6038908; DOI: 10.1126/science.aao3130

• The driver landscape of sporadic chordoma.

  Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB, Farndon SJ, Guzzo C, Hardy C, Latimer C, Butler AP et al.

  Nature communications 2017;8;1;890

  PUBMED: 29026114; PMC: 5638846; DOI: 10.1038/s41467-017-01026-0

• How to use… lymph node biopsy in paediatrics.

  Farndon S, Behjati S, Jonas N and Messahel B

  Archives of disease in childhood. Education and practice edition 2017;102;5;244-248

  PUBMED: 28468821; DOI: 10.1136/archdischild-2015-309634

• Genetics: Taking single-cell transcriptomics to the bedside.

  Behjati S and Haniffa M

  Nature reviews. Clinical oncology 2017;14;10;590-592

  PUBMED: 28762386; DOI: 10.1038/nrclinonc.2017.117

• Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

  Behjati S, Tarpey PS, Haase K, Ye H, Young MD, Alexandrov LB, Farndon SJ, Collord G, Wedge DC, Martincorena I et al.

  Nature communications 2017;8;15936

  PUBMED: 28643781; PMC: 5490007; DOI: 10.1038/ncomms15936

• Molecular diagnoses of century-old childhood tumours.

  Virasami A, Farndon SJ, McDermott U, Sebire N and Behjati S

  The Lancet. Oncology 2017;18;5;e237

  PUBMED: 28495283; DOI: 10.1016/S1470-2045(17)30226-7

• Accurate Breakpoint Mapping in Apparently Balanced Translocation Families with Discordant Phenotypes Using Whole Genome Mate-Pair Sequencing.

  Aristidou C, Koufaris C, Theodosiou A, Bak M, Mehrjouy MM, Behjati F, Tanteles G, Christophidou-Anastasiadou V, Tommerup N and Sismani C

  PloS one 2017;12;1;e0169935

  PUBMED: 28072833; PMC: 5225008; DOI: 10.1371/journal.pone.0169935

2016

• Retracing embryological fate.

  Behjati S

  Science (New York, N.Y.) 2016;354;6316;1109

  PUBMED: 27934728; DOI: 10.1126/science.aal2189

• Mutational signatures of ionizing radiation in second malignancies.

  Behjati S, Gundem G, Wedge DC, Roberts ND, Tarpey PS, Cooke SL, Van Loo P, Alexandrov LB, Ramakrishna M, Davies H et al.

  Nature communications 2016;7;12605

  PUBMED: 27615322; PMC: 5027243; DOI: 10.1038/ncomms12605

• Mutation Screening of BRCA Genes in 10 Iranian Males with Breast Cancer.

  Zorrieh Zahra A, Kadkhoda S, Behjati F, Aghakhani Moghaddam F, Badiei A, Sirati F, Afshin Alavi H, Atri M, Omranipour R and Keyhani E

  International journal of molecular and cellular medicine 2016;5;2;114-22

  PUBMED: 27478808; PMC: 4947216

2015

• Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

  Ju YS, Tubio JM, Mifsud W, Fu B, Davies HR, Ramakrishna M, Li Y, Yates L, Gundem G, Tarpey PS et al.

  Genome research 2015;25;6;814-24

  PUBMED: 25963125; PMC: 4448678; DOI: 10.1101/gr.190470.115

• Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics.

  Presneau N, Baumhoer D, Behjati S, Pillay N, Tarpey P, Campbell PJ, Jundt G, Hamoudi R, Wedge DC, Loo PV et al.

  The journal of pathology. Clinical research 2015;1;2;113-23

  PUBMED: 27499898; PMC: 4858131; DOI: 10.1002/cjp2.13

• Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

  Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S et al.

  Nature genetics 2015;47;3;257-62

  PUBMED: 25642631; DOI: 10.1038/ng.3202

• High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.

  Linnemann C, van Buuren MM, Bies L, Verdegaal EM, Schotte R, Calis JJ, Behjati S, Velds A, Hilkmann H, Atmioui DE et al.

  Nature medicine 2015;21;1;81-5

  PUBMED: 25531942; DOI: 10.1038/nm.3773

2014

• Dysfunction of phospholipase Cγ in immune disorders and cancer.

  Koss H, Bunney TD, Behjati S and Katan M

  Trends in biochemical sciences 2014;39;12;603-11

  PUBMED: 25456276; DOI: 10.1016/j.tibs.2014.09.004

• Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.

  Ju YS, Alexandrov LB, Gerstung M, Martincorena I, Nik-Zainal S, Ramakrishna M, Davies HR, Papaemmanuil E, Gundem G, Shlien A et al.

  eLife 2014;3

  PUBMED: 25271376; PMC: 4371858; DOI: 10.7554/eLife.02935

• Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

  Tubio JMC, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K et al.

  Science (New York, N.Y.) 2014;345;6196;1251343

  PUBMED: 25082706; PMC: 4380235; DOI: 10.1126/science.1251343

• Genome sequencing of normal cells reveals developmental lineages and mutational processes.

  Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC, Tamuri AU, Martincorena I, Petljak M, Alexandrov LB, Gundem G et al.

  Nature 2014;513;7518;422-425

  PUBMED: 25043003; PMC: 4227286; DOI: 10.1038/nature13448

• Processed pseudogenes acquired somatically during cancer development.

  Cooke SL, Shlien A, Marshall J, Pipinikas CP, Martincorena I, Tubio JM, Li Y, Menzies A, Mudie L, Ramakrishna M et al.

  Nature communications 2014;5;3644

  PUBMED: 24714652; PMC: 3996531; DOI: 10.1038/ncomms4644

• Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

  Behjati S, Tarpey PS, Sheldon H, Martincorena I, Van Loo P, Gundem G, Wedge DC, Ramakrishna M, Cooke SL, Pillay N et al.

  Nature genetics 2014;46;4;376-379

  PUBMED: 24633157; PMC: 4032873; DOI: 10.1038/ng.2921

• Wiping versus suction to clear neonatal airways at birth.

  Behjati S

  Lancet (London, England) 2014;383;9918;695

  PUBMED: 24560056; DOI: 10.1016/S0140-6736(14)60257-9

• A pathogenic mosaic TP53 mutation in two germ layers detected by next generation sequencing.

  Behjati S, Maschietto M, Williams RD, Side L, Hubank M, West R, Pearson K, Sebire N, Tarpey P, Futreal A et al.

  PloS one 2014;9;5;e96531

  PUBMED: 24810334; PMC: 4014518; DOI: 10.1371/journal.pone.0096531

2013

• What is next generation sequencing?

  Behjati S and Tarpey PS

  Archives of disease in childhood. Education and practice edition 2013;98;6;236-8

  PUBMED: 23986538; PMC: 3841808; DOI: 10.1136/archdischild-2013-304340

• Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

  Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P, Wedge DC, Cooke SL, Gundem G, Davies H et al.

  Nature genetics 2013;45;12;1479-82

  PUBMED: 24162739; PMC: 3839851; DOI: 10.1038/ng.2814

• Signatures of mutational processes in human cancer.

  Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale AL et al.

  Nature 2013;500;7463;415-21

  PUBMED: 23945592; PMC: 3776390; DOI: 10.1038/nature12477

• Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma.

  Tarpey PS, Behjati S, Cooke SL, Van Loo P, Wedge DC, Pillay N, Marshall J, O'Meara S, Davies H, Nik-Zainal S et al.

  Nature genetics 2013;45;8;923-6

  PUBMED: 23770606; PMC: 3743157; DOI: 10.1038/ng.2668