GDSC: Genomics of Drug Sensitivity in Cancer

GDSC: Genomics of Drug Sensitivity in Cancer

GDSC: Genomics of Drug Sensitivity in Cancer

Overview

The Genomics of Drug Sensitivity in Cancer Project is part of a Wellcome Trust funded collaboration between The Cancer Genome Project at the Wellcome Trust Sanger Institute (UK) and the Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center (USA). This collaboration integrates the expertise at both sites toward the goal of identifying cancer biomarkers that can be used to identify genetically defined subsets of patients most likely to respond to cancer therapies.

We are screening >1000 genetically characterised human cancer cell lines with a wide range of anti-cancer therapeutics. These compounds include cytotoxic chemotherapeutics as well as targeted therapeutics from commercial sources, academic collaborators, and from the biotech and pharmaceutical industries.

The sensitivity patterns of the cell lines are correlated with extensive genomic and expression data to identify genetic features that are predictive of sensitivity. This large collection of cell lines enables us to capture much of the genomic heterogeneity that underlies human cancer, and which appears to play a critical role in determining the variable response of patients to treatment with specific agents.

Our drug sensitivity data and genetic correlations are freely available through our website as a resource to the academic and medical communities.

Contact

cancerrxgene@sanger.ac.uk

Publications

  • Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.

    Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H et al.

    Nucleic acids research 2013;41;Database issue;D955-61

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