Study reveals how sex 'blindspot' could misdirect medical research
Existing drugs could benefit patients with bone cancer, genetic study suggests
A subgroup of patients with osteosarcoma – a form of bone cancer – could be helped by an existing drug, suggest scientists from the Wellcome Trust Sanger Institute and their collaborators. In the largest genetic sequencing study of osteosarcoma to date, scientists discovered that 10 per cent of patients with a genetic mutation in particular growth factor signalling genes may benefit from existing drugs, known as IGF1R inhibitors.
Babies' DNA affects mothers' risk of pre-eclampsia in pregnancy
A major new international study from InterPregGen has revealed, for the first time, that some features in a baby’s DNA can increase the risk of its mother developing pre-eclampsia – a potentially dangerous condition in pregnancy. The five-year study explored the genetic make-up of 4,380 babies born from pre-eclamptic pregnancies and compared their DNA with over 300,000 healthy individuals.
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Cracking Ali Baba's code.
CamOptimus: a tool for exploiting complex adaptive evolution to optimize experiments and processes in biotechnology.
Microbiology (Reading, England) 2017
"Like sugar in milk": reconstructing the genetic history of the Parsi population.
Genome biology 2017;18;1;110
Control of virulence gene transcription by indirect readout in Vibrio cholerae and Salmonella enterica serovar Typhimurium.
Environmental microbiology 2017
Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome.
Genome research 2017
Minimal genetic change in Vibrio cholerae in Mozambique over time: Multilocus variable number tandem repeat analysis and whole genome sequencing.
PLoS neglected tropical diseases 2017;11;6;e0005671
DNA methylation homeostasis in human and mouse development.
Current opinion in genetics & development 2017;43;101-109
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.
The New England journal of medicine 2017
Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.
Nature genetics 2017
Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.
JCI insight 2017;2;12
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Nature neuroscience 2017
You Are What You Eat: A Genomic Analysis of the Gut Microbiome of Captive and Wild Octopus vulgaris Paralarvae and Their Zooplankton Prey.
Frontiers in physiology 2017;8;362