Natural resistance to malaria linked to variation in human red blood cell receptors
Scientists unveil the UK’s largest resource of human stem cells from healthy donors
Reported in Nature, one of the largest sets of high quality human induced pluripotent stem cell lines from healthy individuals has been produced by a consortium involving the Wellcome Trust Sanger Institute. Comprehensively annotated and available for independent research, the hundreds of stem cell lines are a powerful resource for scientists studying human development and disease.
Cancer drug design targeted by COSMIC's new 3D system
COSMIC-3D, the most comprehensive system for exploring cancer mutations in three dimensions, is launched today by COSMIC, based at the Wellcome Trust Sanger Institute, in collaboration with Astex Pharmaceuticals, Cambridge, UK. With extensive colourful and helpful visualisations, the new resource can help identify and characterise drug targets as well as support the design of new therapeutics for cancer.
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Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America 2017
Wounding induces dedifferentiation of epidermal Gata6(+) cells and acquisition of stem cell properties.
Nature cell biology 2017
A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells.
Cell reports 2017;19;7;1479-1493
Megakaryocytes in Myeloproliferative Neoplasms Have Unique Somatic Mutations.
The American journal of pathology 2017
Reshaping the tree of life.
Nature reviews. Microbiology 2017;15;6;322
PGBD5 promotes site-specific oncogenic mutations in human tumors.
Nature genetics 2017
Common genetic variation drives molecular heterogeneity in human iPSCs.
Testing for differential abundance in mass cytometry data.
Nature methods 2017
Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia.
Malaria journal 2017;16;1;195
A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma.
Human mutation 2017
Revisiting olfactory receptors as putative drivers of cancer.
Wellcome open research 2017;2;9
Regulation of bone mass through pineal-derived melatonin-MT2 pathway.
Journal of pineal research 2017
Normalizing single-cell RNA sequencing data: challenges and opportunities.
Nature methods 2017
Molecular diagnoses of century-old childhood tumours.
The Lancet. Oncology 2017;18;5;e237
Haploinsufficiency of ZNF462 is associated with craniofacial anomalies, corpus callosum dysgenesis, ptosis, and developmental delay.
European journal of human genetics : EJHG 2017