EMu: Expectation-Maximisation inference of mutational signatures
EMu is software for inferring the mutational signatures present in a number of cancer mutation sets.
Several independent mutational processes jointly produce the observed spectrum of mutations in a number of comparable tumours. EMu tries to find the number of processes present in a data set and their individual mutational signatures. These signatures contain information about the biological, physical or chemical processes active in cancer.
EMu can also be used to localise regions in a cancer genome where a given set of mutational processes is active. EMu exploits the fact that the outcome of a mutational process not only depends on its signature, but also on the sequence on which it acts.