PlasmoGEM - The Plasmodium Genetic Modification Project

PlasmoGEM - The Plasmodium Genetic Modification Project

PlasmoGEM - The Plasmodium Genetic Modification Project

PlasmoGEM provides the malaria research community with a variety of resources, including:

  • large-insert genomic DNA libraries
  • vectors for targeted genome modification including knock-out and epitope tagging of genes of interests
  • Plasmodium artificial chromosome libraries

All materials used in our pipelines as well as the final products are freely available to the non-profit research community and can be accesed via our dedicated website at http://plasmogem.sanger.ac.uk/.

People

Rayner, Julian C

Rayner, Julian
Dr Julian C Rayner
Senior Group Leader and Director of Wellcome Genome Campus Connecting Science

Groups

Oliver Billker's group uses experimental genetics in rodent models to study the basic biology of malaria parasites and their interactions with host and mosquito vectors

Julian Rayner's group investigates the molecular details of human-parasite interactions during the P. falciparum blood stages, with a particular focus on large-scale experimental approaches to understanding erythrocyte invasion.

Publications

  • PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites.

    Schwach F, Bushell E, Gomes AR, Anar B, Girling G et al.

    Nucleic acids research 2015;43;Database issue;D1176-82

  • A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite.

    Gomes AR, Bushell E, Schwach F, Girling G, Anar B et al.

    Cell host & microbe 2015;17;3;404-13

  • A scalable pipeline for highly effective genetic modification of a malaria parasite.

    Pfander C, Anar B, Schwach F, Otto TD, Brochet M et al.

    Nature methods 2011;8;12;1078-82