Malaria

Malaria

Malaria

Our Approach

malariaprog.pngSanger Institute, Genome Research Limited

We develop and enhance high-throughput tools and technologies for malaria research to enable us to understand specific biological problems relevant for malaria control and to understand the fundamental science of human host, mosquito vector and Plasmodium pathogen.

The Malaria Programme  integrates genomic, genetic and proteomic approaches to:

  • Conduct large-scale, high-resolution analysis of Plasmodium and Anopheles genome variation to understand how they are evolving
  • Investigate genetic interactions between human, parasite and vector populations
  • Use molecular, cellular and organismal model systems to investigate how genetic variation affects host-parasite interactions 
  • Developing scalable technologies and resources for Plasmodium experimental genetics using both in vitro and in vivo model systems
  • Develop new methods to investigate extracellular low-affinity interactions between P. falciparum extracellular proteins and host receptors
IMG_2975.jpgPatients in a waiting room of a health clinic in Biu, Upper East Region of Ghana.

Malaria is a debilitating and sometimes fatal illness that is caused by infection with Plasmodium parasites that are passed between people by Anopheles mosquitoes. Despite progress in fighting the illness, nearly half the world's population - 3.4 billion people in 97 countries - are at risk. In 2012, there were 207 million reported cases and 627,000 deaths, with the majority of deaths among African children under the age of five (WHO Malaria Report, 2013). Developing an effective malaria vaccine and fighting antimalarial drug resistance remain major global public health challenges. 

By integrating genomics with experimental research and operating both at scale, the Malaria programme is uniquely placed to tackle key challenges in malaria control, including the development of effective genomic surveillance of drug and insecticide resistance, and identifying and validating new drug and vaccine targets.

 

Research

The Malaria Programme develops and applies high-throughput and large-scale platforms to significantly expand our understanding of natural genetic variation in human hosts, Plasmodium parasites and Anopheles vector populations; to enable large-scale genetic modification of Plasmodium parasites; and to identify host-parasite protein-protein interactions. We collaborate closely with other Sanger Institute research Programmes, particularly Infection Genomics, Cellular Genetics and Human Genetics.

Groups

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