Cellular Genetics

Cellular Genetics

Cellular Genetics

Our Approach

Stylised image representing single cell analysis
The above image represents a cellular differentiation trajectory resolved by single cell genomics, one of the core technologies employed by groups in the Cellular Genetics Programme.

The Cellular Genetics Programme explores the consequences of genome variation on human cell biology, and thus gene function in health and disease. We conduct large-scale systematic screens to discover the impact of naturally-occurring and engineered genome mutations in human iPS cells, their differentiated derivatives, and other cell types.

The Cellular Genetics Programme will:

  • use induced pluripotential stem cells obtained from 100s of people, healthy and with known genetic diseases, differentiated into macrophages, hepatocytes and pancreatic cells to explore the impact, at the cellular level, of naturally occurring common and rare human variation on:
    • host-pathogen interactions and innate immune responses
    • metabolic responses
  • integrate results from cellular genetics studies with functional genomics data sets and novel algorithms, to study mechanisms of gene regulation and assist the interpretation of disease variation
  • create a full reference map of the epigenome and transcriptome of every cell type in the human body using single-cell techniques
  • further develop CRISPR-Cas technology to perform genome-wide screens of protein coding genes, lnc RNAs and other genome elements in libraries of cells to explore the genomic components influencing a range of cellular phenotypes.
  • develop and enhance innovative methods for analysis of data from single-cell studies
Our Work

The Cellular Genetics Programme investigates cell biology and human disease in the fields of infection, innate immunity and metabolism by focusing on cell types implicated in these processes, including the macrophage, the hepatocyte and the pancreatic beta cell.

We are also starting a project that seeks to create a comprehensive reference map of the type and properties of all human cells, the fundamental unit of life, as a basis for understanding, diagnosing, monitoring and treating health and disease.

Research

Groups

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