The major theme of our research is the study of genome variation: naturally occurring and engineered, inherited and somatic, in humans, pathogens, human cells and mice.

Our science is organised into seven scientific Programmes, each defining a major area of research with a particular biological, disease or analytic focus. In all cases the studies provide insights into human, pathogen, cellular evolution, the phenotypic and hence biological consequences of genome variation and the processes which cause mutations.

We aim to carry out studies that are of a design and scale that cannot be conducted in most biomedical research institutes.

Our Bold Approach