Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.
Proceedings of the National Academy of Sciences of the United States of America 2015;112;45;13850-5
Regulation of mitochondrial morphology and function by stearoylation of TFR1.
Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans.
International journal of obesity (2005) 2015;39;7;1151-60
Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation.
Proceedings of the National Academy of Sciences of the United States of America 2015;112;2;506-11
A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.
American journal of human genetics 2014;95;5;584-589
Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.
Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.
Below thermoneutrality, changes in activity do not drive changes in total daily energy expenditure between groups of mice.
Cell metabolism 2012;16;5;665-71
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.
Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice.
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance.
Nature medicine 2010;16;9;1001-8
Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation.
Nature medicine 2009;15;3;259-66
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
Cell metabolism 2008;7;5;389-99
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.
PLoS genetics 2007;3;4;e64
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.
PLoS biology 2006;4;11;e369
The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.