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Antonio Vidal-Puig
Group Leader

I am a Professor of Molecular Nutrition and Metabolism at Cambridge University. My main activity is to do research as a Principal Investigator at the Medical Research Council Metabolic Disease Unit (MRC MDU Unit) and at the Wellcome trust Sanger Institute. I serve as Scientific Director of the Cambridge Phenomics Center, a state-of-the-art center that applies multidisciplinary approaches to murine metabolic phenotyping. I also see patients as an Honorary Consultant in Metabolic Medicine at Addenbrooke’s Hospital.  

Research Programmes


  • Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.

    Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN et al.

    Proceedings of the National Academy of Sciences of the United States of America 2015;112;45;13850-5

  • Regulation of mitochondrial morphology and function by stearoylation of TFR1.

    Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL et al.

    Nature 2015;525;7567;124-8

  • Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans.

    Virtue S, Masoodi M, de Weijer BA, van Eijk M, Mok CY et al.

    International journal of obesity (2005) 2015;39;7;1151-60

  • Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation.

    Patel MN, Bernard WG, Milev NB, Cawthorn WP, Figg N et al.

    Proceedings of the National Academy of Sciences of the United States of America 2015;112;2;506-11

  • A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.

    Clemente FJ, Cardona A, Inchley CE, Peter BM, Jacobs G et al.

    American journal of human genetics 2014;95;5;584-589

  • Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.

    Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A et al.

    Diabetes 2015;64;4;1180-92

  • Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.

    Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G et al.

    Diabetes 2013;62;11;3697-708

  • Below thermoneutrality, changes in activity do not drive changes in total daily energy expenditure between groups of mice.

    Virtue S, Even P and Vidal-Puig A

    Cell metabolism 2012;16;5;665-71

  • BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.

    Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E et al.

    Cell 2012;149;4;871-85

  • Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice.

    Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L et al.

    Diabetes 2011;60;3;797-809

  • Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance.

    López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR et al.

    Nature medicine 2010;16;9;1001-8

  • Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation.

    Ishii KA, Fumoto T, Iwai K, Takeshita S, Ito M et al.

    Nature medicine 2009;15;3;259-66

  • Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

    López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ et al.

    Cell metabolism 2008;7;5;389-99

  • PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.

    Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S et al.

    PLoS genetics 2007;3;4;e64

  • Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

    Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM et al.

    PLoS biology 2006;4;11;e369

  • The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.

    Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M et al.

    Diabetes 2005;54;6;1706-16