The Vidal-Puig group focuses on obesity and diabetes and more specifically trying to understand why being obese causes cardiometabolic complications. We feel that this link is the accumulation of fat in the heart, muscle or liver and we feel that if we understand this link we may be able to prevent obese people from dying from heart attacks or developing diabetes. For this we study how to prevent the accumulation of lipids in these organs through activation of the brown fat, a type of fat which helps to prevent obesity and diabetes.
We aim to learn why being obese causes metabolic and cardiovascular problems and to provide the rational for mechanistically driven therapeutic approaches to prevent these complications which are the meain cause of morbidity amongst obese patients. The projects we will develop at the Sanger Institute includes a focus on human iPS white and brown adipose tissue funded by ERC and phenotyping characterisation of murine models relevant for obesity and metabolic complications.