Sanger Institute, Genome Research Limited


Skarnes, Bill
Dr Bill Skarnes
Group Leader



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  • Off-target mutations are rare in Cas9-modified mice.

    Iyer V, Shen B, Zhang W, Hodgkins A, Keane T et al.

    Nature methods 2015;12;6;479

  • WGE: a CRISPR database for genome engineering.

    Hodgkins A, Farne A, Perera S, Grego T, Parry-Smith DJ et al.

    Bioinformatics (Oxford, England) 2015;31;18;3078-80

  • Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.

    Yeung AT, Hale C, Xia J, Tate PH, Goulding D et al.

    Scientific reports 2015;5;8908

  • Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.

    Shen B, Zhang W, Zhang J, Zhou J, Wang J et al.

    Nature methods 2014;11;4;399-402