This is an archive page of the work that the Sequence Variation Infrastructure team undertook at the Sanger Institute and is being retained as a historical record. When its leader, Dr Thomas Keane, moved to EMBL-EBI to head up the European Nucleotide Archive (ENA) and European Genome-phenome Archive (EGA) in November 2016, the group members moved to other research teams to continue their work.

Sanger Institute, Genome Research Limited


Keane, Thomas
Dr Thomas Keane
Group Leader

Thomas Keane led the Sequence Variation Infrastructure group. His interests were in using genomic technologies to learn about biological processes with a particular focus on mouse and human disease. He is now based at EMBL-EBI.

Key Projects, Collaborations, Tools & Data

Here are some of the outputs of the team.

Research Programmes

Partners and Funders

Internal Partners
External Partners and Funders


  • Mouse genomic variation and its effect on phenotypes and gene regulation.

    Keane TM, Goodstadt L, Danecek P, White MA, Wong K et al.

    Nature 2011;477;7364;289-94

  • Sequence-based characterization of structural variation in the mouse genome.

    Yalcin B, Wong K, Agam A, Goodson M, Keane TM et al.

    Nature 2011;477;7364;326-9

  • The genomic landscape shaped by selection on transposable elements across 18 mouse strains.

    Nellåker C, Keane TM, Yalcin B, Wong K, Agam A et al.

    Genome biology 2012;13;6;R45

  • Sequencing and characterization of the FVB/NJ mouse genome.

    Wong K, Bumpstead S, Van Der Weyden L, Reinholdt LG, Wilming LG et al.

    Genome biology 2012;13;8;R72

  • The Mouse Genomes Project: a repository of inbred laboratory mouse strain genomes.

    Adams DJ, Doran AG, Lilue J and Keane TM

    Mammalian genome : official journal of the International Mammalian Genome Society 2015;26;9-10;403-12