Reik, Wolf
Professor Wolf Reik, FRS, FMedSci
Group Leader

Wolf Reik is interested in epigenetic gene regulation in mammalian development. His current research focuses on epigenetic heterogeneity in development and ageing, making use of single cell genomics. He is a founding member of the Single Cell Genomics Centre since 2013.  

Key Projects, Collaborations, Tools & Data

Our key collaborations at Sanger are with the Single Cell Genomics Centre, particularly with the Marioni, Teichmann, Stegle, Voet, and Hemberg groups. This is focussed on methods development for single cells including new computational and modelling approaches. There are a number of projects that the Centre is involved in, including decoding cell fate decision making during gastrulation, and the development of novel tools for lineage tracing during embryogenesis, which are supported by Wellcome Trust awards. 

Research Programmes

Partners and Funders

Internal Partners


  • Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.

    von Meyenn F, Iurlaro M, Habibi E, Liu NQ, Salehzadeh-Yazdi A et al.

    Molecular cell 2016;62;6;848-61

  • Maternal DNA Methylation Regulates Early Trophoblast Development.

    Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M et al.

    Developmental cell 2016;36;2;152-63

  • Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity.

    Angermueller C, Clark SJ, Lee HJ, Macaulay IC, Teng MJ et al.

    Nature methods 2016;13;3;229-32

  • Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity.

    Smallwood SA, Lee HJ, Angermueller C, Krueger F, Saadeh H et al.

    Nature methods 2014;11;8;817-20

  • FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency.

    Ficz G, Hore TA, Santos F, Lee HJ, Dean W et al.

    Cell stem cell 2013;13;3;351-9

  • The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells.

    Seisenberger S, Andrews S, Krueger F, Arand J, Walter J et al.

    Molecular cell 2012;48;6;849-62

  • Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.

    Booth MJ, Branco MR, Ficz G, Oxley D, Krueger F et al.

    Science (New York, N.Y.) 2012;336;6083;934-7

  • The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r.

    Keniry A, Oxley D, Monnier P, Kyba M, Dandolo L et al.

    Nature cell biology 2012;14;7;659-65

  • Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.

    Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F et al.

    Nature 2011;473;7347;398-402

  • Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

    Popp C, Dean W, Feng S, Cokus SJ, Andrews S et al.

    Nature 2010;463;7284;1101-5