Odom Group | Regulatory evolution in mammalian tissues

Odom Group | Regulatory evolution in mammalian tissues

Odom Group

4761.jpgSanger Institute, Genome Research Limited

Our Research and Approach

We compare how transcription and transcriptional regulation vary during evolution, and the implications this regulatory plasticity has for diseases such as cancer. We use numerous new high-throughput methods combined with analysis of multiple mammals and vertebrates to reveal fundamental biological insights into tissue-specification and genome evolution.

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Dr Duncan Odom
Group Leader

Duncan Odom's research group compares how transcription and transcriptional regulation vary during evolution, and the implications this regulatory plasticity has for diseases such as cancer. His team uses numerous new high-throughput methods combined with analysis of multiple mammals and vertebrates to reveal fundamental biological insights into tissue-specification and genome evolution.

Research Programmes

Partners and Funders

In addition to many collaborators at the Sanger Institute and The Cambridge Research Institute (CRI), we also work closely with a number of sister groups, including those of:
External Partners and Funders

Publications

  • Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages.

    Schmidt D, Schwalie PC, Wilson MD, Ballester B, Gonçalves A et al.

    Cell 2012;148;1-2;335-48

  • Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes.

    Kutter C, Brown GD, Gonçalves A, Wilson MD, Watt S et al.

    Nature genetics 2011;43;10;948-55

  • Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding.

    Schmidt D, Wilson MD, Ballester B, Schwalie PC, Brown GD et al.

    Science (New York, N.Y.) 2010;328;5981;1036-40

  • A CTCF-independent role for cohesin in tissue-specific transcription.

    Schmidt D, Schwalie PC, Ross-Innes CS, Hurtado A, Brown GD et al.

    Genome research 2010;20;5;578-88

  • Evolution of transcriptional control in mammals.

    Wilson MD and Odom DT

    Current opinion in genetics & development 2009;19;6;579-85

  • Species-specific transcription in mice carrying human chromosome 21.

    Wilson MD, Barbosa-Morais NL, Schmidt D, Conboy CM, Vanes L et al.

    Science (New York, N.Y.) 2008;322;5900;434-8

  • Tissue-specific transcriptional regulation has diverged significantly between human and mouse.

    Odom DT, Dowell RD, Jacobsen ES, Gordon W, Danford TW et al.

    Nature genetics 2007;39;6;730-2

  • Control of pancreas and liver gene expression by HNF transcription factors.

    Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ et al.

    Science (New York, N.Y.) 2004;303;5662;1378-81