Model Pipelines produce and characterise knock-out mice for large-scale research projects, including the Sanger Mouse Genetics Project, KOMP2, EUCOMMTools, and the Infrafrontier projects
The team provides high-throughput genotyping and characterisation of mutant mouse strains created either by targeted embryonic stem cells or CRISPR/Cas9 gene editing
The Mouse Phenotyping team delivers phenotypic characterisation of mutant mice, typically knockouts of protein coding genes. Phenotyping encompasses a standardised set of more than 600 clinical parameters, and covers key biomedical areas such as reproduction, development, infection and immunity, musculoskeletal system, metabolism and endocrinology.
The Transgenic Technologies group produces mutant mice by utilising modified ES cell and Crispr/Cas9. All lines produced are cryopreserved and available for use by the wider scientific community.