People

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Dr Ramiro Ramirez-Solis, PhD
Group Leader

I work with a large team of superb scientists to generate mutant mouse strains carrying alleles of biomedical importance. Our work includes design of the mutation, mutagenesis of mouse ES cells, CRISPR mutagenesis, transgenic technologies to transfer the allele into the germline, molecular analysis and genotyping, colony management, cryopreservation, phenotypic analysis, and strain distribution.

Key Projects, Collaborations, Tools & Data

The main component of work our greatly contributes to the International Mouse Phenotyping Consortium, which aims to discover the function of all of the genes in the mouse genome that code for proteins by the use of a broad-spectrum standardised phenotyping platform and dataset. Our mouse strains and data are used by scientists throughout the world, reducing the amount of unnecessary experimental duplication and ensuring a 'gold standard' of models for research groups to study.

Partners and Funders

Internal Partners

Publications

  • Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach.

    Scavizzi F, Ryder E, Newman S, Raspa M, Gleeson D et al.

    Transgenic research 2015;24;5;921-7

  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

    Hrabě de Angelis M, Nicholson G, Selloum M, White JK, Morgan H et al.

    Nature genetics 2015;47;9;969-78

  • Deubiquitinase MYSM1 Is Essential for Normal Fetal Liver Hematopoiesis and for the Maintenance of Hematopoietic Stem Cells in Adult Bone Marrow.

    Förster M, Belle JI, Petrov JC, Ryder EJ, Clare S and Nijnik A

    Stem cells and development 2015;24;16;1865-77

  • Rapid conversion of EUCOMM/KOMP-CSD alleles in mouse embryos using a cell-permeable Cre recombinase.

    Ryder E, Doe B, Gleeson D, Houghton R, Dalvi P et al.

    Transgenic research 2014;23;1;177-85

  • Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

    Maguire S, Estabel J, Ingham N, Pearson S, Ryder E et al.

    PloS one 2014;9;3;e91807

  • Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.

    Ryder E, Gleeson D, Sethi D, Vyas S, Miklejewska E et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2013;24;7-8;286-94

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.

    Ryder E, Wong K, Gleeson D, Keane TM, Sethi D et al.

    Genesis (New York, N.Y. : 2000) 2013;51;7;523-8

  • Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.

    Basel-Vanagaite L, Dallapiccola B, Ramirez-Solis R, Segref A, Thiele H et al.

    American journal of human genetics 2012;91;6;998-1010

  • The mammalian gene function resource: the International Knockout Mouse Consortium.

    Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;9-10;580-6

  • Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.

    Ayadi A, Birling MC, Bottomley J, Bussell J, Fuchs H et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;9-10;600-10

  • The role of sphingosine-1-phosphate transporter Spns2 in immune system function.

    Nijnik A, Clare S, Hale C, Chen J, Raisen C et al.

    Journal of immunology (Baltimore, Md. : 1950) 2012;189;1;102-11

  • Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.

    Bassett JH, Gogakos A, White JK, Evans H, Jacques RM et al.

    PLoS genetics 2012;8;8;e1002858