Molecular Cytogenetics | Scientific Operations

Molecular Cytogenetics | Scientific Operations

Molecular Cytogenetics

cytogenetics-23.jpgSanger Institute, Genome Research Limited

Our Research and Approach

Multiplex-FISH and Fibre-FISH

Fluorescence in situ hybridisation (FISH) is a laboratory technique for detecting and locating specific DNA sequences on metaphase chromosomes and interphase nuclei. The technique relies on exposing the chromosome to a small DNA sequence called a probe that has a fluorescent molecule attached to it. The probe will only anneal to the complementary sequences under optimised condition. Simultaneous hybrisation of multiple probes, each lablled with a different fluorescent dye or a different combination of multiple dyes, allows multiple targets in a single specimen to be visualised in one hybridisation. FISH thus enables the link between genomics and cyotgeneitcs.

Nearly all our services rely on FISH, including physical mapping by metaphase-, interphase- and fibre-FISH; karyotyping of cancer and reprogrammed cell lines by Multiplex-FISH, studying the evolutionary chromosome rearrangement by cross-species chromosome painting etc.

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People

Yang, Fengtang
Fengtang Yang
Group Leader

Fengtang Yang is a senior staff scientist and the manager of cytogentics core facility. He studies chromosomes, their structure, inheritance and evolution by fluorescence in situ hybridisation (FISH).

Key Projects, Collaborations, Tools & Data

Here are some of the outputs of the team.

Partners and Funders

Internal Partners

Publications

  • Obesity, starch digestion and amylase: association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes.

    Carpenter D, Dhar S, Mitchell LM, Fu B, Tyson J et al.

    Human molecular genetics 2015;24;12;3472-80

  • Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.

    Agu CA, Soares FA, Alderton A, Patel M, Ansari R et al.

    Stem cell reports 2015;5;4;660-71

  • Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

    Ju YS, Tubio JM, Mifsud W, Fu B, Davies HR et al.

    Genome research 2015;25;6;814-24

  • A First Generation Comparative Chromosome Map between Guinea Pig (Cavia porcellus) and Humans.

    Romanenko SA, Perelman PL, Trifonov VA, Serdyukova NA, Li T et al.

    PloS one 2015;10;5;e0127937

  • Expansion of the HSFY gene family in pig lineages : HSFY expansion in suids.

    Skinner BM, Lachani K, Sargent CA, Yang F, Ellis P et al.

    BMC genomics 2015;16;442

  • Multidirectional chromosome painting substantiates the occurrence of extensive genomic reshuffling within Accipitriformes.

    Nie W, O'Brien PC, Fu B, Wang J, Su W et al.

    BMC evolutionary biology 2015;15;205

  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.

    Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C et al.

    Nature medicine 2014;20;11;1340-1347

  • Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage.

    Murchison EP, Wedge DC, Alexandrov LB, Fu B, Martincorena I et al.

    Science (New York, N.Y.) 2014;343;6169;437-440

  • Genetic basis of Y-linked hearing impairment.

    Wang Q, Xue Y, Zhang Y, Long Q, Asan et al.

    American journal of human genetics 2013;92;2;301-6

  • Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome.

    Gribble SM, Wiseman FK, Clayton S, Prigmore E, Langley E et al.

    PloS one 2013;8;4;e60482

  • Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer.

    Murchison EP, Schulz-Trieglaff OB, Ning Z, Alexandrov LB, Bauer MJ et al.

    Cell 2012;148;4;780-91

  • Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

    McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G et al.

    PLoS genetics 2012;8;11;e1003022

  • Genomic evidence reveals a radiation of placental mammals uninterrupted by the KPg boundary.

    Liu L, Zhang J, Rheindt FE, Lei F, Qu Y et al.

    Proceedings of the National Academy of Sciences of the United States of America 2017;114;35;E7282-E7290

  • A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation.

    Li MA, Amaral PP, Cheung P, Bergmann JH, Kinoshita M et al.

    eLife 2017;6

  • Karyotype Evolution and Phylogenetic Relationships of Cricetulus sokolovi Orlov et Malygin 1988 (Cricetidae, Rodentia) Inferred from Chromosomal Painting and Molecular Data.

    Poplavskaya NS, Romanenko SA, Serdyukova NA, Trifonov VA, Yang F et al.

    Cytogenetic and genome research 2017

  • Complex Chromosomal Rearrangements by Single Catastrophic Pathogenesis in NUT Midline Carcinoma.

    Lee JK, Louzada S, An Y, Kim SY, Kim S et al.

    Annals of oncology : official journal of the European Society for Medical Oncology 2017

  • Recurrent Rearrangements of Human Amylase Genes Create Multiple Independent CNV Series.

    Shwan NA, Louzada S, Yang F and Armour JA

    Human mutation 2017

  • Chromosomal phylogeny of Vampyressine bats (Chiroptera, Phyllostomidae) with description of two new sex chromosome systems.

    Gomes AJ, Nagamachi CY, Rodrigues LR, Benathar TC, Ribas TF et al.

    BMC evolutionary biology 2016;16;1;119

  • Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.

    Poznik GD, Xue Y, Mendez FL, Willems TF, Massaia A et al.

    Nature genetics 2016;48;6;593-9

  • Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.

    Davison A, McDowell GS, Holden JM, Johnson HF, Koutsovoulos GD et al.

    Current biology : CB 2016;26;5;654-60

  • Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.

    Maresch R, Mueller S, Veltkamp C, Öllinger R, Friedrich M et al.

    Nature communications 2016;7;10770

  • Chromosome engineering in zygotes with CRISPR/Cas9.

    Boroviak K, Doe B, Banerjee R, Yang F and Bradley A

    Genesis (New York, N.Y. : 2000) 2016;54;2;78-85

  • The pig X and Y Chromosomes: structure, sequence, and evolution.

    Skinner BM, Sargent CA, Churcher C, Hunt T, Herrero J et al.

    Genome research 2016;26;1;130-9

  • Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.

    Espana-Agusti J, Zou X, Wong K, Fu B, Yang F et al.

    PloS one 2016;11;2;e0148055

  • Genomic Alteration in Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Inferred from Karyotyping, Molecular Cytogenetics, and Array Comparative Genomic Hybridization.

    Singchat W, Hitakomate E, Rerkarmnuaychoke B, Suntronpong A, Fu B et al.

    PloS one 2016;11;8;e0160901

  • Karyotypic Evolution in Malagasy Flying Foxes (Pteropodidae, Chiroptera) and Their Hipposiderid Relatives as Determined by Comparative Chromosome Painting.

    Richards LR, Rambau RV, Goodman SM, Taylor PJ, Schoeman MC et al.

    Cytogenetic and genome research 2016;148;2-3;185-98

  • Rapid Karyotype Evolution in Lasiopodomys Involved at Least Two Autosome - Sex Chromosome Translocations.

    Gladkikh OL, Romanenko SA, Lemskaya NA, Serdyukova NA, O'Brien PC et al.

    PloS one 2016;11;12;e0167653

  • Genome-wide comparative chromosome maps of Arvicola amphibius, Dicrostonyx torquatus, and Myodes rutilus.

    Romanenko SA, Lemskaya NA, Trifonov VA, Serdyukova NA, O'Brien PC et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2015

  • CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.

    Weber J, Öllinger R, Friedrich M, Ehmer U, Barenboim M et al.

    Proceedings of the National Academy of Sciences of the United States of America 2015;112;45;13982-7

  • A novel satellite DNA sequence in the Peromyscus genome (PMSat): Evolution via copy number fluctuation.

    Louzada S, Vieira-da-Silva A, Mendes-da-Silva A, Kubickova S, Rubes J et al.

    Molecular phylogenetics and evolution 2015;92;193-203

  • Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.

    Agu CA, Soares FA, Alderton A, Patel M, Ansari R et al.

    Stem cell reports 2015;5;4;660-71

  • Integration of molecular cytogenetics, dated molecular phylogeny, and model-based predictions to understand the extreme chromosome reorganization in the Neotropical genus Tonatia (Chiroptera: Phyllostomidae).

    Sotero-Caio CG, Volleth M, Hoffmann FG, Scott L, Wichman HA et al.

    BMC evolutionary biology 2015;15;220

  • A global reference for human genetic variation.

    1000 Genomes Project Consortium, Auton A, Brooks LD, Durbin RM, Garrison EP et al.

    Nature 2015;526;7571;68-74

  • Multidirectional chromosome painting substantiates the occurrence of extensive genomic reshuffling within Accipitriformes.

    Nie W, O'Brien PC, Fu B, Wang J, Su W et al.

    BMC evolutionary biology 2015;15;205

  • Obesity, starch digestion and amylase: association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes.

    Carpenter D, Dhar S, Mitchell LM, Fu B, Tyson J et al.

    Human molecular genetics 2015;24;12;3472-80

  • Expansion of the HSFY gene family in pig lineages : HSFY expansion in suids.

    Skinner BM, Lachani K, Sargent CA, Yang F, Ellis P et al.

    BMC genomics 2015;16;442

  • Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

    Ju YS, Tubio JM, Mifsud W, Fu B, Davies HR et al.

    Genome research 2015;25;6;814-24

  • Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy.

    Polley S, Louzada S, Forni D, Sironi M, Balaskas T et al.

    Proceedings of the National Academy of Sciences of the United States of America 2015;112;16;5105-10

  • Correction: Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.

    Ding Z, Ni Y, Timmer SW, Lee BK, Battenhouse A et al.

    PLoS genetics 2015;11;4;e1005177

  • Large-scale discovery of novel genetic causes of developmental disorders.

    Deciphering Developmental Disorders Study

    Nature 2015;519;7542;223-8

  • A First Generation Comparative Chromosome Map between Guinea Pig (Cavia porcellus) and Humans.

    Romanenko SA, Perelman PL, Trifonov VA, Serdyukova NA, Li T et al.

    PloS one 2015;10;5;e0127937

  • A High-Resolution Comparative Chromosome Map of Cricetus cricetus and Peromyscus eremicus Reveals the Involvement of Constitutive Heterochromatin in Breakpoint Regions.

    Vieira-da-Silva A, Louzada S, Adega F and Chaves R

    Cytogenetic and genome research 2015;145;1;59-67

  • Phylogenetic reconstruction by cross-species chromosome painting and G-banding in four species of Phyllostomini tribe (Chiroptera, Phyllostomidae) in the Brazilian Amazon: an independent evidence for monophyly.

    Ribas TF, Rodrigues LR, Nagamachi CY, Gomes AJ, Rissino Jd et al.

    PloS one 2015;10;3;e0122845

  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.

    Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C et al.

    Nature medicine 2014;20;11;1340-1347

  • Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.

    Ding Z, Ni Y, Timmer SW, Lee BK, Battenhouse A et al.

    PLoS genetics 2014;10;11;e1004798

  • Sequence of a complete chicken BG haplotype shows dynamic expansion and contraction of two gene lineages with particular expression patterns.

    Salomonsen J, Chattaway JA, Chan AC, Parker A, Huguet S et al.

    PLoS genetics 2014;10;6;e1004417

  • Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage.

    Murchison EP, Wedge DC, Alexandrov LB, Fu B, Martincorena I et al.

    Science (New York, N.Y.) 2014;343;6169;437-440

  • Haptoglobin (HP) and Haptoglobin-related protein (HPR) copy number variation, natural selection, and trypanosomiasis.

    Hardwick RJ, Ménard A, Sironi M, Milet J, Garcia A et al.

    Human genetics 2014;133;1;69-83

  • Chromosomal evolution among leaf-nosed nectarivorous bats--evidence from cross-species chromosome painting (Phyllostomidae, Chiroptera).

    Sotero-Caio CG, Volleth M, Gollahon LS, Fu B, Cheng W et al.

    BMC evolutionary biology 2013;13;276

  • CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans.

    Aklillu E, Odenthal-Hesse L, Bowdrey J, Habtewold A, Ngaimisi E et al.

    BMC infectious diseases 2013;13;536

  • A phylogenetic analysis using multidirectional chromosome painting of three species (Uroderma magnirostrum, U. bilobatum and Artibeus obscurus) of subfamily Stenodermatinae (Chiroptera-Phyllostomidae).

    Pieczarka JC, Gomes AJ, Nagamachi CY, Rocha DC, Rissino JD et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2013;21;4;383-92

  • The zebrafish reference genome sequence and its relationship to the human genome.

    Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C et al.

    Nature 2013;496;7446;498-503

  • Genetic basis of Y-linked hearing impairment.

    Wang Q, Xue Y, Zhang Y, Long Q, Asan et al.

    American journal of human genetics 2013;92;2;301-6

  • Fine mapping of the pond snail left-right asymmetry (chirality) locus using RAD-Seq and fibre-FISH.

    Liu MM, Davey JW, Banerjee R, Han J, Yang F et al.

    PloS one 2013;8;8;e71067

  • Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome.

    Gribble SM, Wiseman FK, Clayton S, Prigmore E, Langley E et al.

    PloS one 2013;8;4;e60482

  • Tracking chromosome evolution in southern African gerbils using flow-sorted chromosome paints.

    Knight LI, Ng BL, Cheng W, Fu B, Yang F and Rambau RV

    Cytogenetic and genome research 2013;139;4;267-75

  • A comprehensive molecular cytogenetic analysis of chromosome rearrangements in gibbons.

    Capozzi O, Carbone L, Stanyon RR, Marra A, Yang F et al.

    Genome research 2012;22;12;2520-8

  • Generation of diversity by somatic mutation in the Camelus dromedarius T-cell receptor gamma variable domains.

    Vaccarelli G, Antonacci R, Tasco G, Yang F, Giordano L et al.

    European journal of immunology 2012;42;12;3416-28

  • Praomys tullbergi (Muridae, Rodentia) genome architecture decoded by comparative chromosome painting with Mus and Rattus.

    Chaves R, Louzada S, Meles S, Wienberg J and Adega F

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2012;20;6;673-83

  • Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer.

    Murchison EP, Schulz-Trieglaff OB, Ning Z, Alexandrov LB, Bauer MJ et al.

    Cell 2012;148;4;780-91

  • Estimation of rearrangement phylogeny for cancer genomes.

    Greenman CD, Pleasance ED, Newman S, Yang F, Fu B et al.

    Genome research 2012;22;2;346-61

  • Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system.

    Huang Y, Pettitt SJ, Guo G, Liu G, Li MA et al.

    Nucleic acids research 2012;40;3;e21

  • Chromosomal rearrangements and karyotype evolution in carnivores revealed by chromosome painting.

    Nie W, Wang J, Su W, Wang D, Tanomtong A et al.

    Heredity 2012;108;1;17-27

  • Defining the sister rat mammary tumor cell lines HH-16 cl.2/1 and HH-16.cl.4 as an in vitro cell model for Erbb2.

    Louzada S, Adega F and Chaves R

    PloS one 2012;7;1;e29923

  • Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

    McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G et al.

    PLoS genetics 2012;8;11;e1003022

  • Molecular cytogenetics: karyotype evolution, phylogenomics and future prospects.

    Robinson TJ and Yang F

    Heredity 2012;108;1;1-3

  • The Deciphering Developmental Disorders (DDD) study.

    Firth HV, Wright CF and DDD Study

    Developmental medicine and child neurology 2011;53;8;702-3

  • Comparative cytogenetic mapping of Sox2 and Sox14 in cichlid fishes and inferences on the genomic organization of both genes in vertebrates.

    Mazzuchelli J, Yang F, Kocher TD and Martins C

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2011;19;5;657-67

  • ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma.

    Loizou JI, Sancho R, Kanu N, Bolland DJ, Yang F et al.

    Cancer cell 2011;19;5;587-600

  • Chromosome painting in Tragulidae facilitates the reconstruction of Ruminantia ancestral karyotype.

    Kulemzina AI, Yang F, Trifonov VA, Ryder OA, Ferguson-Smith MA and Graphodatsky AS

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2011;19;4;531-9

  • High-resolution chromosome painting reveals the first genetic signature for the chiropteran suborder Pteropodiformes (Mammalia: Chiroptera).

    Volleth M, Yang F and Müller S

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2011;19;4;507-19

  • Reconstruction of karyotype evolution in core Glires. I. The genome homology revealed by comparative chromosome painting.

    Beklemisheva VR, Romanenko SA, Biltueva LS, Trifonov VA, Vorobieva NV et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2011;19;4;549-65

  • Massive genomic rearrangement acquired in a single catastrophic event during cancer development.

    Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR et al.

    Cell 2011;144;1;27-40

  • PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.

    Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G et al.

    Science (New York, N.Y.) 2010;330;6007;1104-7

  • Karyotypic evolution in family Hipposideridae (Chiroptera, Mammalia) revealed by comparative chromosome painting, G- and C-banding.

    Mao XG, Wang JH, Su WT, Wang YX, Yang FT and Nie WH

    Dong wu xue yan jiu = Zoological research / "Dong wu xue yan jiu" bian ji wei yuan hui bian ji 2010;31;5;453-60

  • Cross-species chromosome painting in bats from Madagascar: the contribution of Myzopodidae to revealing ancestral syntenies in Chiroptera.

    Richards LR, Rambau RV, Lamb JM, Taylor PJ, Yang F et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2010;18;6;635-53

  • Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling.

    van Harn T, Foijer F, van Vugt M, Banerjee R, Yang F et al.

    Genes & development 2010;24;13;1377-88

  • Chromosomal evolution of Arvicolinae (Cricetidae, Rodentia). III. Karyotype relationships of ten Microtus species.

    Lemskaya NA, Romanenko SA, Golenishchev FN, Rubtsova NV, Sablina OV et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2010;18;4;459-71

  • Characterization of two human lung adenocarcinoma cell lines by reciprocal chromosome painting.

    Peng KJ, Wang JH, Su WT, Wang XC, Yang FT and Nie WH

    Dong wu xue yan jiu = Zoological research 2010;31;2;113-21

  • Signatures of mutation and selection in the cancer genome.

    Bignell GR, Greenman CD, Davies H, Butler AP, Edkins S et al.

    Nature 2010;463;7283;893-8

  • Cross-species chromosome painting corroborates microchromosome fusion during karyotype evolution of birds.

    Hansmann T, Nanda I, Volobouev V, Yang F, Schartl M et al.

    Cytogenetic and genome research 2009;126;3;281-304

  • Different evolutionary trails in the related genomes Cricetus cricetus and Peromyscus eremicus (Rodentia, Cricetidae) uncovered by orthologous satellite DNA repositioning.

    Louzada S, Paço A, Kubickova S, Adega F, Guedes-Pinto H et al.

    Micron (Oxford, England : 1993) 2008;39;8;1149-55

  • Copy number variation and evolution in humans and chimpanzees.

    Perry GH, Yang F, Marques-Bonet T, Murphy C, Fitzgerald T et al.

    Genome research 2008;18;11;1698-710

  • Adaptive evolution of UGT2B17 copy-number variation.

    Xue Y, Sun D, Daly A, Yang F, Zhou X et al.

    American journal of human genetics 2008;83;3;337-46

  • Flying lemurs--the 'flying tree shrews'? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade.

    Nie W, Fu B, O'Brien PC, Wang J, Su W et al.

    BMC biology 2008;6;18

  • [An analysis on chromosome X, Y and 18 in the spermatozoa of asthenospermia patients by triple-color fluorescence in situ hybridization].

    Li LB, Xia YK, Li XS, Lü J, Ma MF et al.

    Zhonghua nan ke xue = National journal of andrology 2008;14;3;211-4

  • Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration.

    Smith JR, Maguire S, Davis LA, Alexander M, Yang F et al.

    Stem cells (Dayton, Ohio) 2008;26;2;496-504

  • Chromosome painting shows that skunks (Mephitidae, Carnivora) have highly rearranged karyotypes.

    Perelman PL, Graphodatsky AS, Dragoo JW, Serdyukova NA, Stone G et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2008;16;8;1215-31

  • Finishing the finished human chromosome 22 sequence.

    Cole CG, McCann OT, Collins JE, Oliver K, Willey D et al.

    Genome biology 2008;9;5;R78

  • Multidirectional cross-species painting illuminates the history of karyotypic evolution in Perissodactyla.

    Trifonov VA, Stanyon R, Nesterenko AI, Fu B, Perelman PL et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2008;16;1;89-107

  • Construction, characterization, and chromosomal mapping of a fosmid library of the white-cheeked gibbon (Nomascus leucogenys).

    Chen L, Ye J, Liu Y, Wang J, Su W et al.

    Genomics, proteomics & bioinformatics 2007;5;3-4;207-15

  • Paired-end mapping reveals extensive structural variation in the human genome.

    Korbel JO, Urban AE, Affourtit JP, Godwin B, Grubert F et al.

    Science (New York, N.Y.) 2007;318;5849;420-6

  • Definition of the zebrafish genome using flow cytometry and cytogenetic mapping.

    Freeman JL, Adeniyi A, Banerjee R, Dallaire S, Maguire SF et al.

    BMC genomics 2007;8;195

  • Flow analysis and sorting of microchromosomes (<3 Mb).

    Ng BL, Yang F and Carter NP

    Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71;6;410-3

  • Chromosome painting among Proboscidea, Hyracoidea and Sirenia: support for Paenungulata (Afrotheria, Mammalia) but not Tethytheria.

    Pardini AT, O'Brien PC, Fu B, Bonde RK, Elder FF et al.

    Proceedings. Biological sciences / The Royal Society 2007;274;1615;1333-40

  • A high utility integrated map of the pig genome.

    Humphray SJ, Scott CE, Clark R, Marron B, Bender C et al.

    Genome biology 2007;8;7;R139

  • Cross-species chromosome painting among camel, cattle, pig and human: further insights into the putative Cetartiodactyla ancestral karyotype.

    Balmus G, Trifonov VA, Biltueva LS, O'Brien PC, Alkalaeva ES et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2007;15;4;499-515

  • Mapping of KIT adjacent sequences on canid autosomes and B chromosomes.

    Yudkin DV, Trifonov VA, Kukekova AV, Vorobieva NV, Rubtsova NV et al.

    Cytogenetic and genome research 2007;116;1-2;100-3

  • Phylogenomics of the genus Mus (Rodentia; Muridae): extensive genome repatterning is not restricted to the house mouse.

    Veyrunes F, Dobigny G, Yang F, O'Brien PC, Catalan J et al.

    Proceedings. Biological sciences / The Royal Society 2006;273;1604;2925-34

  • Comparative genomic analysis links karyotypic evolution with genomic evolution in the Indian muntjac (Muntiacus muntjak vaginalis).

    Zhou Q, Huang L, Zhang J, Zhao X, Zhang Q et al.

    Chromosoma 2006;115;6;427-36

  • Reciprocal chromosome painting between three laboratory rodent species.

    Romanenko SA, Perelman PL, Serdukova NA, Trifonov VA, Biltueva LS et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2006;17;12;1183-92

  • Global variation in copy number in the human genome.

    Redon R, Ishikawa S, Fitch KR, Feuk L, Perry GH et al.

    Nature 2006;444;7118;444-54

  • High-density comparative BAC mapping in the black muntjac (Muntiacus crinifrons): molecular cytogenetic dissection of the origin of MCR 1p+4 in the X1X2Y1Y2Y3 sex chromosome system.

    Huang L, Chi J, Wang J, Nie W, Su W and Yang F

    Genomics 2006;87;5;608-15

  • Phylogenomics of several deer species revealed by comparative chromosome painting with Chinese muntjac paints.

    Huang L, Chi J, Nie W, Wang J and Yang F

    Genetica 2006;127;1-3;25-33

  • Are molecular cytogenetics and bioinformatics suggesting diverging models of ancestral mammalian genomes?

    Froenicke L, Caldés MG, Graphodatsky A, Müller S, Lyons LA et al.

    Genome research 2006;16;3;306-10

  • Chromosome painting between human and lorisiform prosimians: evidence for the HSA 7/16 synteny in the primate ancestral karyotype.

    Nie W, O'Brien PC, Fu B, Wang J, Su W et al.

    American journal of physical anthropology 2006;129;2;250-9

  • Chromosomal mechanisms underlying the karyotype evolution of the oriental voles (Muridae, Eothenomys).

    Li T, Wang J, Su W and Yang F

    Cytogenetic and genome research 2006;114;1;50-5

  • Karyotypic evolution of a novel cervid satellite DNA family isolated by microdissection from the Indian muntjac Y-chromosome.

    Li YC, Cheng YM, Hsieh LJ, Ryder OA, Yang F et al.

    Chromosoma 2005;114;1;28-38

  • Sex reversal syndrome (64,XY; SRY-positive) in a mare demonstrating masculine behaviour.

    Switonski M, Chmurzynska A, Szczerbal I, Lipczynski A, Yang F and Nowicka-Posłuszna A

    Journal of animal breeding and genetics = Zeitschrift für Tierzüchtung und Züchtungsbiologie 2005;122 Suppl 1;60-3

  • The impact of chromosome sorting and painting on the comparative analysis of primate genomes.

    Ferguson-Smith MA, Yang F, Rens W and O'Brien PC

    Cytogenetic and genome research 2005;108;1-3;112-21

  • New insights into the karyotypic relationships of Chinese muntjac (Muntiacus reevesi), forest musk deer (Moschus berezovskii) and gayal (Bos frontalis).

    Chi J, Fu B, Nie W, Wang J, Graphodatsky AS and Yang F

    Cytogenetic and genome research 2005;108;4;310-6

  • Reciprocal chromosome painting between two South American bats: Carollia brevicauda and Phyllostomus hastatus (Phyllostomidae, Chiroptera).

    Pieczarka JC, Nagamachi CY, O'Brien PC, Yang F, Rens W et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2005;13;4;339-47

  • Comparative map between the domestic pig and dog.

    Biltueva LS, Yang F, Vorobieva NV and Graphodatsky AS

    Mammalian genome : official journal of the International Mammalian Genome Society 2004;15;10;809-18

  • Cross-species chromosome painting in the golden mole and elephant-shrew: support for the mammalian clades Afrotheria and Afroinsectiphillia but not Afroinsectivora.

    Robinson TJ, Fu B, Ferguson-Smith MA and Yang F

    Proceedings. Biological sciences / The Royal Society 2004;271;1547;1477-84

  • Applications of combined DNA microarray and chromosome sorting technologies.

    Gribble SM, Fiegler H, Burford DC, Prigmore E, Yang F et al.

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2004;12;1;35-43

  • Chromosome painting in the long-tailed field mouse provides insights into the ancestral murid karyotype.

    Stanyon R, Yang F, Morescalchi AM and Galleni L

    Cytogenetic and genome research 2004;105;2-4;406-11

  • Comparative chromosome painting between the domestic pig (Sus scrofa) and two species of peccary, the collared peccary (Tayassu tajacu) and the white-lipped peccary (T. pecari): a phylogenetic perspective.

    Bosma AA, de Haan NA, Arkesteijn GJ, Yang F, Yerle M and Zijlstra C

    Cytogenetic and genome research 2004;105;1;115-21

  • Refined genome-wide comparative map of the domestic horse, donkey and human based on cross-species chromosome painting: insight into the occasional fertility of mules.

    Yang F, Fu B, O'Brien PC, Nie W, Ryder OA and Ferguson-Smith MA

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2004;12;1;65-76

  • Nonmosaic X trisomy, detected by chromosome painting, in an infertile mare.

    Bugno M, Slota E, Wieczorek M, Yang F, Buczynski J and Switonski M

    Equine veterinary journal 2003;35;2;209-10

  • Reciprocal chromosome painting among human, aardvark, and elephant (superorder Afrotheria) reveals the likely eutherian ancestral karyotype.

    Yang F, Alkalaeva EZ, Perelman PL, Pardini AT, Harrison WR et al.

    Proceedings of the National Academy of Sciences of the United States of America 2003;100;3;1062-6

  • Comparative chromosome painting defines the karyotypic relationships among the domestic dog, Chinese raccoon dog and Japanese raccoon dog.

    Nie W, Wang J, Perelman P, Graphodatsky AS and Yang F

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2003;11;8;735-40

  • Two cases of infertile bitches with 78,XX/77,X mosaic karyotype: a need for cytogenetic evaluation of dogs with reproductive disorders.

    Switonski M, Szczerbal I, Grewling J, Antosik P, Nizanski W and Yang F

    The Journal of heredity 2003;94;1;65-8

  • [Comparative chromosome painting shows the red panda (Ailurus fulgens) has a highly conserved karyotype].

    Tian Y, Nie WH, Wang JH, Yang YF and Yang FT

    Yi chuan xue bao = Acta genetica Sinica 2002;29;2;124-7

  • Chromosome painting refines the history of genome evolution in hares and rabbits (order Lagomorpha).

    Robinson TJ, Yang F and Harrison WR

    Cytogenetic and genome research 2002;96;1-4;223-7

  • Comparative molecular cytogenetic studies in the order Carnivora: mapping chromosomal rearrangements onto the phylogenetic tree.

    Graphodatsky AS, Yang F, Perelman PL, O'Brien PC, Serdukova NA et al.

    Cytogenetic and genome research 2002;96;1-4;137-45

  • Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung.

    Varmeh-Ziaie S, Ichimura K, Yang F, Rabbits P and Collins VP

    Cancer letters 2001;174;2;179-87

  • Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

    Zhang Q, Skepper JN, Yang F, Davies JD, Hegyi L et al.

    Journal of cell science 2001;114;Pt 24;4485-98

  • A classification efficiency test of spectral karyotyping and multiplex fluorescence in situ hybridization: identification of chromosome homologies between Homo sapiens and Hylobates leucogenys.

    Rens W, Yang F, O'Brien PC, Solanky N and Ferguson-Smith MA

    Genes, chromosomes & cancer 2001;31;1;65-74

  • Multicolor Fluorescence In Situ Hybridization (FISH) approaches for simultaneous analysis of the entire human genome.

    Lee C, Rens W and Yang F

    Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2001;Chapter 4;Unit4.9

  • An X-Y paint set and sperm FISH protocol that can be used for validation of cattle sperm separation procedures.

    Rens W, Yang F, Welch G, Revell S, O'Brien PC et al.

    Reproduction (Cambridge, England) 2001;121;4;541-6

  • Conserved chromosome segments in Hylobates hoolock revealed by human and H. leucogenys paint probes.

    Nie W, Rens W, Wang J and Yang F

    Cytogenetics and cell genetics 2001;92;3-4;248-53

  • Genomic organization of the human metabotropic glutamate receptor subtype 3.

    Corti C, Sala CF, Yang F, Corsi M, Xuereb JH and Ferraguti F

    Journal of neurogenetics 2000;14;4;207-25, 271

  • Seven cosmid-derived canine microsatellites.

    Dolf G, Schelling C, Stahlberger-Saitbekova N, Fu B, Schläpfer J and Yang F

    Animal genetics 2000;31;6;411-2

  • Use of flow-sorted canine chromosomes in the assignment of canine linkage, radiation hybrid, and syntenic groups to chromosomes: refinement and verification of the comparative chromosome map for dog and human.

    Sargan DR, Yang F, Squire M, Milne BS, O'Brien PC and Ferguson-Smith MA

    Genomics 2000;69;2;182-95

  • Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice.

    Baker M, Gamble J, Tooze R, Higgins D, Yang FT et al.

    The EMBO journal 2000;19;17;4644-54

  • Multiplex fluorescence in situ hybridization and cross species color banding of a case of chronic myeloid leukemia in blastic crisis with a complex Philadelphia translocation.

    Harrison CJ, Gibbons B, Yang F, Butler T, Cheung KL et al.

    Cancer genetics and cytogenetics 2000;116;2;105-10

  • A complete comparative chromosome map for the dog, red fox, and human and its integration with canine genetic maps.

    Yang F, O'Brien PC, Milne BS, Graphodatsky AS, Solanky N et al.

    Genomics 1999;62;2;189-202

  • [Determination of trisomy 9p by molecular cytogenetic technology].

    Ding X, Sanoudou D, Yang F and Chen H

    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 1999;16;6;383-5

  • The integration of canine genetic maps with the canine karyotype using specific gene amplification of chromosome-specific DNA.

    Sargan DR, Yang F, Milne B, O'Brien PC, Solanky N et al.

    Animal biotechnology 1999;10;3;159-64

  • Complete homology maps of the rabbit (Oryctolagus cuniculus) and human by reciprocal chromosome painting.

    Korstanje R, O'Brien PC, Yang F, Rens W, Bosma AA et al.

    Cytogenetics and cell genetics 1999;86;3-4;317-22

  • Mapping chromosomal homologies between humans and two langurs (Semnopithecus francoisi and S. phayrei) by chromosome painting.

    Nie W, Liu R, Chen Y, Wang J and Yang F

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 1998;6;6;447-53

  • Defining the anatomy of the Rangifer tarandus sex chromosomes.

    Lee C, Griffin DK, O'Brien PC, Yang F, Lin CC and Ferguson-Smith MA

    Chromosoma 1998;107;1;61-9

  • Use of the Indian muntjac idiogram to align conserved chromosomal segments in sheep and human genomes by chromosome painting.

    Burkin DJ, Yang F, Broad TE, Wienberg J, Hill DF and Ferguson-Smith MA

    Genomics 1997;46;1;143-7

  • Previously hidden chromosome aberrations in T(12;15)-positive BALB/c plasmacytomas uncovered by multicolor spectral karyotyping.

    Coleman AE, Schröck E, Weaver Z, du Manoir S, Yang F et al.

    Cancer research 1997;57;20;4585-92

  • [A comparative chromosome map between human and Hylobates hoolock built by chromosome painting].

    Yu D, Yang F and Liu R

    Yi chuan xue bao = Acta genetica Sinica 1997;24;5;417-23

  • Chromosomal evolution of the Chinese muntjac (Muntiacus reevesi).

    Yang F, O'Brien PC, Wienberg J, Neitzel H, Lin CC and Ferguson-Smith MA

    Chromosoma 1997;106;1;37-43

  • A reappraisal of the tandem fusion theory of karyotype evolution in Indian muntjac using chromosome painting.

    Yang F, O'Brien PC, Wienberg J and Ferguson-Smith MA

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 1997;5;2;109-17

  • Comparative chromosome painting in mammals: human and the Indian muntjac (Muntiacus muntjak vaginalis).

    Yang F, Müller S, Just R, Ferguson-Smith MA and Wienberg J

    Genomics 1997;39;3;396-401