Somatic mutations accumulate in all cells throughout life. They are responsible for cancer development, some developmental disorders and are believed to contribute to ageing. Yet, despite their critical importance, very little is known about the extent of somatic evolution in normal tissues due to traditional technical limitations. Our group investigates somatic mutation and evolution in healthy tissues and its implications for cancer development and ageing by combining genome sequencing, laser capture microscopy and bioinformatics. We also work towards developing better computational methods for cancer genomics.