We are developing and applying methods to explore the genome, epigenome and transcriptome of single cells in order to better understand normal development and disease processes.
We have been granted a strategic award from the Wellcome Trust 'The Homunculus in our Thymus: A Cellular Genomics Approach' that enables us to investigate how thymic epithelial cells (TEC) - irrespective of their cell identity - remarkably can express virtually the complete set of protein-coding genes. These studies are relevant to better understand the fundamental function of the immune system and to identify causes of autoimmune diseases.
We are a part of:
We explore the consequences of genome variation on human cell biology, and thus gene function in health and disease. We conduct large-scale systematic screens to discover the impact of naturally-occurring and engineered genome mutations in human iPS cells, their differentiated derivatives, and other cell types.
Adrian's group is investigating "The function of long non-coding RNAs originating at CpG island promoters" and "The effects of a methylated DNA binding protein on gene expression"
Single cell epigenomics applied to development and ageing
Our aim is to offer a high-quality, high-throughput single cell sequencing service that enables Faculty to study and understand cellular heterogeneity and it’s role in health and disease. We further want to create a collaborative and open environment to foster single cell method development.
Thierry Voet's group focuses on developing methods that characterise the DNA and RNA in a single cell to enable the exploration of DNA-mutation, the genetic differences between cells in a person's body and the relation of this diversity to disease.