Archive Page: Logan Group | Genetics of Behaviour

Archive Page: Logan Group | Genetics of Behaviour

Archive Page: Logan Group

Archive Page - this page is maintained as a historical record and is no longer being updated. Darren Logan was at the Sanger Institute from 2010 to June 2016 when he left to join Mars Incorporated to lead their basic research programmes into sensory mechanisms and feeding behaviour at the WALTHAM Centre for Pet Nutrition. This page was last edited in 2016.
Logan GroupSanger Institute, Genome Research Limited
Logan Group

Our Research and Approach

The Genetics of Behaviour laboratory used mice as a model system to identify the genes and neural circuits that underpin social and learned behaviours, perception and cognition.

The Faculty leader, Darren Logan, was at the Sanger Institute from 2010 to June 2016 when he left to join Mars Incorporated to lead their basic research programmes into sensory mechanisms and feeding behaviour at the WALTHAM Centre for Pet Nutrition.

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Darren Logan, PhD
Group Leader

Darren Logan was at the Sanger Institute from 2010 to June 2016 when he left to join Mars Incorporated to lead their basic research programmes into sensory mechanisms and feeding behaviour at the WALTHAM Centre for Pet Nutrition.

At the Sanger Institute Darren Logan studied genes that enable animals to detect, interpret and respond to sensory signals with an appropriate behaviour. His interests encompass neuronal genomics and transcriptomics, innate and learned behavioural analyses, animal modelling and genome sequencing of humans with rare neurological disorders.

Key Projects, Collaborations, Tools & Data

Partners and Funders

External Partners and Funders

Publications

  • Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior.

    Dey S, Chamero P, Pru JK, Chien MS, Ibarra-Soria X et al.

    Cell 2015;161;6;1334-44

  • Molecular and neuronal homology between the olfactory systems of zebrafish and mouse.

    Saraiva LR, Ahuja G, Ivandic I, Syed AS, Marioni JC et al.

    Scientific reports 2015;5;11487

  • Do you smell what I smell? Genetic variation in olfactory perception.

    Logan DW

    Biochemical Society transactions 2014;42;4;861-5

  • The olfactory transcriptomes of mice.

    Ibarra-Soria X, Levitin MO, Saraiva LR and Logan DW

    PLoS genetics 2014;10;9;e1004593

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • Genomic variation in the vomeronasal receptor gene repertoires of inbred mice.

    Wynn EH, Sánchez-Andrade G, Carss KJ and Logan DW

    BMC genomics 2012;13;415

  • Olfaction and olfactory-mediated behaviour in psychiatric disease models.

    Huckins LM, Logan DW and Sánchez-Andrade G

    Cell and tissue research 2013;354;1;69-80

  • Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

    McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G et al.

    PLoS genetics 2012;8;11;e1003022

  • Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq.

    Saraiva LR, Ibarra-Soria X, Khan M, Omura M, Scialdone A et al.

    Scientific reports 2015;5;18178

  • Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

    Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL et al.

    Proceedings of the National Academy of Sciences of the United States of America 2017

  • Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.

    Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D et al.

    Molecular metabolism 2017;6;5;383-392

  • Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.

    Ibarra-Soria X, Nakahara TS, Lilue J, Jiang Y, Trimmer C et al.

    eLife 2017;6

  • Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.

    Ambrosi TH, Scialdone A, Graja A, Gohlke S, Jank AM et al.

    Cell stem cell 2017

  • Revisiting olfactory receptors as putative drivers of cancer.

    Ranzani M, Iyer V, Ibarra-Soria X, Del Castillo Velasco-Herrera M, Garnett M et al.

    Wellcome open research 2017;2;9

  • Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.

    Untiet V, Moeller LM, Ibarra-Soria X, Sánchez-Andrade G, Stricker M et al.

    Chemical senses 2016

  • Loss of Mrap2 is associated with Sim 1 deficiency and increased circulating cholesterol.

    Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn E et al.

    The Journal of endocrinology 2016

  • Detection of pup odors by non-canonical adult vomeronasal neurons expressing an odorant receptor gene is influenced by sex and parenting status.

    Nakahara TS, Cardozo LM, Ibarra-Soria X, Bard AD, Carvalho VM et al.

    BMC biology 2016;14;1;12

  • Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq.

    Saraiva LR, Ibarra-Soria X, Khan M, Omura M, Scialdone A et al.

    Scientific reports 2015;5;18178

  • Pregnancy and estrogen enhance neural progenitor-cell proliferation in the vomeronasal sensory epithelium.

    Oboti L, Ibarra-Soria X, Pérez-Gómez A, Schmid A, Pyrski M et al.

    BMC biology 2015;13;104

  • Molecular and neuronal homology between the olfactory systems of zebrafish and mouse.

    Saraiva LR, Ahuja G, Ivandic I, Syed AS, Marioni JC et al.

    Scientific reports 2015;5;11487

  • Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior.

    Dey S, Chamero P, Pru JK, Chien MS, Ibarra-Soria X et al.

    Cell 2015;161;6;1334-44

  • Testing the Toxicofera: comparative transcriptomics casts doubt on the single, early evolution of the reptile venom system.

    Hargreaves AD, Swain MT, Logan DW and Mulley JF

    Toxicon : official journal of the International Society on Toxinology 2014;92;140-56

  • A genome-wide association study of anorexia nervosa.

    Boraska V, Franklin CS, Floyd JA, Thornton LM, Huckins LM et al.

    Molecular psychiatry 2014;19;10;1085-94

  • The olfactory transcriptomes of mice.

    Ibarra-Soria X, Levitin MO, Saraiva LR and Logan DW

    PLoS genetics 2014;10;9;e1004593

  • Do you smell what I smell? Genetic variation in olfactory perception.

    Logan DW

    Biochemical Society transactions 2014;42;4;861-5

  • Restriction and recruitment-gene duplication and the origin and evolution of snake venom toxins.

    Hargreaves AD, Swain MT, Hegarty MJ, Logan DW and Mulley JF

    Genome biology and evolution 2014;6;8;2088-95

  • 27th International Mammalian Genome Conference meeting report.

    Gamache B, Leist SR, Bard AD, Logan DW and Carpanini SM

    Mammalian genome : official journal of the International Mammalian Genome Society 2014;25;5-6;195-201

  • The genomic basis of vomeronasal-mediated behaviour.

    Ibarra-Soria X, Levitin MO and Logan DW

    Mammalian genome : official journal of the International Mammalian Genome Society 2014;25;1-2;75-86

  • Olfaction and olfactory-mediated behaviour in psychiatric disease models.

    Huckins LM, Logan DW and Sánchez-Andrade G

    Cell and tissue research 2013;354;1;69-80

  • Generation of the Sotos syndrome deletion in mice.

    Migdalska AM, van der Weyden L, Ismail O, Sanger Mouse Genetics Project, Rust AG et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;11-12;749-57

  • Learned recognition of maternal signature odors mediates the first suckling episode in mice.

    Logan DW, Brunet LJ, Webb WR, Cutforth T, Ngai J and Stowers L

    Current biology : CB 2012;22;21;1998-2007

  • Genomic variation in the vomeronasal receptor gene repertoires of inbred mice.

    Wynn EH, Sánchez-Andrade G, Carss KJ and Logan DW

    BMC genomics 2012;13;415

  • Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

    McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G et al.

    PLoS genetics 2012;8;11;e1003022

  • Context-dependent individualization of nucleotides and virtual genomic hybridization allow the precise location of human SNPs.

    Reyes J, Gómez-Romero L, Ibarra-Soria X, Palacios-Flores K, Arriola LR et al.

    Proceedings of the National Academy of Sciences of the United States of America 2011;108;37;15294-9

  • The mouse genetics toolkit: revealing function and mechanism.

    van der Weyden L, White JK, Adams DJ and Logan DW

    Genome biology 2011;12;6;224

  • Olfactory mechanisms of stereotyped behavior: on the scent of specialized circuits.

    Stowers L and Logan DW

    Current opinion in neurobiology 2010;20;3;274-80

  • The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs.

    Papes F, Logan DW and Stowers L

    Cell 2010;141;4;692-703

  • Identification of protein pheromones that promote aggressive behaviour.

    Chamero P, Marton TF, Logan DW, Flanagan K, Cruz JR et al.

    Nature 2007;450;7171;899-902

  • Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions.

    Kaler G, Truong DM, Sweeney DE, Logan DW, Nagle M et al.

    Biochemical and biophysical research communications 2006;351;4;872-6

  • Regulation of pigmentation in zebrafish melanophores.

    Logan DW, Burn SF and Jackson IJ

    Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2006;19;3;206-13

  • Large-scale analysis of gene structure in rhodopsin-like GPCRs: evidence for widespread loss of an ancient intron.

    Bryson-Richardson RJ, Logan DW, Currie PD and Jackson IJ

    Gene 2004;338;1;15-23

  • The structure and evolution of the melanocortin and MCH receptors in fish and mammals.

    Logan DW, Bryson-Richardson RJ, Pagán KE, Taylor MS, Currie PD and Jackson IJ

    Genomics 2003;81;2;184-91