Lawniczak Group | Vector-parasite interactions

Lawniczak Group | Vector-parasite interactions

Lawniczak Group

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Our Research and Approach

We carry out our research both here at Sanger and at our fieldsites in Uganda and Mali. We are working to answer the following questions using a variety of genomics tools from whole genome sequencing to single cell RNAseq.

  • How has natural selection shaped the genomes of wild mosquitoes, and what is the impact of this on parasite transmission and vector control?
  • How do human malaria parasites behave inside of the human host to enhance their probability of transmission?
  • How will gene drive work in the face of so much genetic diversity segregating within African Anopheles species.
  • What genes are important for determining mosquito susceptibility to human malaria parasites? And how much does this depend on the parasite genotype and the bacteria/viruses/fungi inside the mosquito?
  • How does mating status of a female influence her susceptibility to malaria parasites?
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People

Lawniczak, Mara
Dr Mara Lawniczak
Group Leader
Mara is an evolutionary geneticist interested in understanding what makes some mosquitoes better than others at transmitting malaria. She’s also likes to keep up to speed with new technologies that enhance our understanding of genomes.

Key Projects, Collaborations, Tools & Data

Research Programmes

Partners and Funders

We are funded by the MRC and the Wellcome Trust
Internal Partners
External Partners and Funders

Publications

  • Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.

    Neafsey DE, Waterhouse RM, Abai MR, Aganezov SS, Alekseyev MA et al.

    Science (New York, N.Y.) 2015;347;6217;1258522

  • Mosquito genomics. Extensive introgression in a malaria vector species complex revealed by phylogenomics.

    Fontaine MC, Pease JB, Steele A, Waterhouse RM, Neafsey DE et al.

    Science (New York, N.Y.) 2015;347;6217;1258524

  • SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.

    Neafsey DE, Lawniczak MK, Park DJ, Redmond SN, Coulibaly MB et al.

    Science (New York, N.Y.) 2010;330;6003;514-7

  • Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences.

    Lawniczak MK, Emrich SJ, Holloway AK, Regier AP, Olson M et al.

    Science (New York, N.Y.) 2010;330;6003;512-4

  • Mosquito genomics. Extensive introgression in a malaria vector species complex revealed by phylogenomics.

    Fontaine MC, Pease JB, Steele A, Waterhouse RM, Neafsey DE et al.

    Science (New York, N.Y.) 2015;347;6217;1258524

  • Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.

    Neafsey DE, Waterhouse RM, Abai MR, Aganezov SS, Alekseyev MA et al.

    Science (New York, N.Y.) 2015;347;6217;1258522

  • Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.

    Talman AM, Prieto JH, Marques S, Ubaida-Mohien C, Lawniczak M et al.

    Malaria journal 2014;13;315

  • Genetic dissection of Anopheles gambiae gut epithelial responses to Serratia marcescens.

    Stathopoulos S, Neafsey DE, Lawniczak MK, Muskavitch MA and Christophides GK

    PLoS pathogens 2014;10;3;e1003897

  • Adaptive divergence between incipient species of Anopheles gambiae increases resistance to Plasmodium.

    White BJ, Lawniczak MK, Cheng C, Coulibaly MB, Wilson MD et al.

    Proceedings of the National Academy of Sciences of the United States of America 2011;108;1;244-9

  • SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.

    Neafsey DE, Lawniczak MK, Park DJ, Redmond SN, Coulibaly MB et al.

    Science (New York, N.Y.) 2010;330;6003;514-7

  • Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences.

    Lawniczak MK, Emrich SJ, Holloway AK, Regier AP, Olson M et al.

    Science (New York, N.Y.) 2010;330;6003;512-4

  • Adaptive gene expression divergence inferred from population genomics.

    Holloway AK, Lawniczak MK, Mezey JG, Begun DJ and Jones CD

    PLoS genetics 2007;3;10;2007-13

  • Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster.

    Lawniczak MK and Begun DJ

    Molecular biology and evolution 2007;24;9;1944-51

  • A QTL analysis of female variation contributing to refractoriness and sperm competition in Drosophila melanogaster.

    Lawniczak MK and Begun DJ

    Genetical research 2005;86;2;107-14

  • A genome-wide analysis of courting and mating responses in Drosophila melanogaster females.

    Lawniczak MK and Begun DJ

    Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 2004;47;5;900-10