Informatics Support Group
High Performance Computing
Sanger Institute, Genome Research Limited
Throughout life, the genome within cells of the human body is exposed to DNA damage and suffers mistakes in replication. These corrosive influences result in progressive, subtle divergence of the DNA sequence in each cell from that originally constituted in the fertilised egg. The Cancer Genome Project uses high-throughput genome sequencing to identify these somatically acquired mutations with the aim of characterising cancer genes, mutational processes and patterns of clonal evolution in human tumours.
Human Genetics Informatics (HGI) supports the scientific aims of the Human Genetics programme by developing and operating computational analysis workflows, managing shared storage, and providing bioinformatics software tools for the use of researchers across all Human Genetics faculty groups.
Provide World Class High Performance Computing and First Class Production Platforms and Services for genome research.
NPG are reliant on the Sanger systems teams for providing solid compute and storage.
Chiang GT, Clapham P, Qi G, Sale K and Coates G
BMC bioinformatics 2011;12;361