Understanding how genetic and genomic variation drives susceptibility to immune-mediated diseases.
The Barrett team studies how genetic variation affects risk for diseases, and finds ways to apply that knowledge to improve health care.
We are a multidisciplinary team that combines large-scale genetic and genomic approaches, and studies in model organisms, to understand the aetiology of various metabolic diseases. We are also actively engaged in developing partnerships with collaborators in Africa focused on applying genomic approaches to study diseases of relevance to Africa and its peoples.
The knowledge of genetic predisposition is important to help those at high risk for these disorders to develop healthier lifestyles and to avoid risky behaviours (such as high fat diets). It can also lead to the development of better drugs that work in each affected individual.
Population and evolutionary genomics, novel computational genomics methods, and related mathematical and statistical models.
The Hurles group studies the genetic causes and mechanisms of rare genetic disorders and how DNA mutates as it is pass on from one generation to the next.
Our research focuses on global health and populations, assessing human diversity and its impact on the burden and aetiology of infectious and non-communicable diseases.
Our research focuses on the application of large-scale genomic analysis to unravel the spectrum of human genetic variation associated with cardiometabolic diseases, and its interaction with non-genetic and environmental cues.
We study variation in the DNA of people from different parts of the world, and also in related species such as chimpanzees and gorillas. This tells us about the evolutionary history of human populations and also allows us to compare the different species.
Our research aims to help identify the genetic determinants of complex human traits by using next-generation association studies to detect novel disease loci.