Archive Page: Grant Group | Genes to cognition

Archive Page: Grant Group | Genes to cognition

Archive Page: Grant Group

The Genes to cognition group moved to the University of Edinburgh in November 2011. We are maintaining this page as a historical record of the group's research at the Sanger Institute. To find out the latest about the group's research, please visit the Genes to Cognition website.

Our Research and Approach

Please note: This page was last updated in November 2011.

The Genes to cognition group moved to the University of Edinburgh in November 2011. We are maintaining this page as a historical record of the group's research at the Sanger Institute. To find out the latest about the group's research, please visit the Genes to Cognition website.

The team, headed by Seth Grant, examines the effect of knocking out specific genetic functions on the molecular architecture of the synapse, the junction between adjacent nerve cells in the brain, in the mouse and relating this information back to man. Synapse junctions are large, complex molecular structures that perform important functions ranging from transmitting nerve impulses to decoding the patterns of electrical activity and translating that information into behaviour and memory. The team uses a broad integrated approach that draws on the many specialties of modern molecular genetics, from highly specific genetic manipulation techniques to complex computational programming and analysis of large quantities of data. Understanding how minor changes in gene sequence affect the molecules that comprise the synapse junction, will aid in the understanding of brain diseases such as Alzheimers, and of mental illnesses, such as schizophrenia.

Read More

Publications

  • Characterization of the proteome, diseases and evolution of the human postsynaptic density.

    Bayés A, van de Lagemaat LN, Collins MO, Croning MD, Whittle IR et al.

    Nature neuroscience 2011;14;1;19-21

  • A general basis for cognition in the evolution of synapse signaling complexes.

    Grant SG

    Cold Spring Harbor symposia on quantitative biology 2009;74;249-57

  • Neurotransmitters drive combinatorial multistate postsynaptic density networks.

    Coba MP, Pocklington AJ, Collins MO, Kopanitsa MV, Uren RT et al.

    Science signaling 2009;2;68;ra19

  • Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.

    Fernández E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH et al.

    Molecular systems biology 2009;5;269

  • A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability.

    Zalfa F, Eleuteri B, Dickson KS, Mercaldo V, De Rubeis S et al.

    Nature neuroscience 2007;10;5;578-87

  • Network activity-independent coordinated gene expression program for synapse assembly.

    Valor LM, Charlesworth P, Humphreys L, Anderson CN and Grant SG

    Proceedings of the National Academy of Sciences of the United States of America 2007;104;11;4658-63

  • Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.

    Cuthbert PC, Stanford LE, Coba MP, Ainge JA, Fink AE et al.

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27;10;2673-82

  • Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome.

    Collins MO, Husi H, Yu L, Brandon JM, Anderson CN et al.

    Journal of neurochemistry 2006;97 Suppl 1;16-23

  • The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour.

    Pocklington AJ, Cumiskey M, Armstrong JD and Grant SG

    Molecular systems biology 2006;2;2006.0023

  • Proteomic analysis of in vivo phosphorylated synaptic proteins.

    Collins MO, Yu L, Coba MP, Husi H, Campuzano I et al.

    The Journal of biological chemistry 2005;280;7;5972-82

  • SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor.

    Komiyama NH, Watabe AM, Carlisle HJ, Porter K, Charlesworth P et al.

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22;22;9721-32

  • Isolation of 2000-kDa complexes of N-methyl-D-aspartate receptor and postsynaptic density 95 from mouse brain.

    Husi H and Grant SG

    Journal of neurochemistry 2001;77;1;281-91

  • Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.

    Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM et al.

    Nature 1998;396;6710;433-9

  • Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.

    Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P and Kandel ER

    Science (New York, N.Y.) 1992;258;5090;1903-10

  • Peroral small-intestinal biopsy: experience with the hydraulic multiple biopsy instrument in routine clinical practice.

    Scott BB and Losowsky MS

    Gut 1976;17;9;740-3