We have broad research interests in a variety of areas of genetics and genomics, often in collaboration with others, using novel computational, statistical and modelling techniques. Current research projects include the following:
Sequencing individuals with related parents, such as from the UK Pakistani community, to discover homozygous rare loss of function mutations, in collaboration with David van Heel at QMUL, Richard Trembath at KCL and others. (Hilary Martin and Vagheesh Narasimhan)
Development of a panel of human iPS cell lines in the HipSci project and collection of genomic data on them for cellular genetic studies, with Daniel Gaffney and Ludovic Vallier at the Sanger Institute, Oliver Stegle at the EBI, Fiona Watt at KCL, Angus Lamond at Dundee and others. (Yasin Memari, Petr Danecek and Reena Halai)
Sequencing cichlid fishes from Lake Malawi and nearby lakes and rivers to study speciation and genomic evolution, with Associate Faculty member Eric Miska, George Turner from Bangor University and Martin Genner from Bristol University. (Milan Malinsky and Hannes Svardal)
Sequencing ancient DNA samples and modelling human population movements and evolutionary history. (Laurits Skov and Vladimir Shchur)
Development of new novel graph-based reference genome structures and mapping software in the context of the Global Alliance for Genomics and Health. (Erik Garrison and Eric Dawson)
Development of efficient computational methods for very large scale haplotype sequence compression and matching using positional Burrows-Wheeler transform (PBWT) approaches and applying them to population inference and imputation, including in the context of a collaboration with Jonathan Marchini at Oxford and Goncalo Abecasis at Michigan to build a very large scale haplotype reference panel in the Haplotype Reference Consortium. (Shane McCarthy and Petr Danecek)
For previous group members and their research areas click on "Read More".