Archive Page: Carter Group | Molecular Cytogenetics

Archive Page: Carter Group | Molecular Cytogenetics

Archive Page: Carter Group

The Molecular Cytogenetics group was led by Dr Nigel Carter until his retirement in May 2012. The team continues to work under Alex Bateman, who now leads the EBI's Protein Services. The group was then led by Dr Matt Hurles. We are maintaining this page as a historical record of the group's activities at the Sanger Institute.

Our Research and Approach

Please note: This page was last updated in May 2012.

The Molecular Cytogenetics team investigates ways of detecting changes in the numbers of genes and chromosomes both in the human and in other organisms that could shed light on the causes of certain inherited disorders in man. The team was led by Dr Nigel Carter, who retired from the Institute on 1 May 2012. His research group is now led by Dr Matthew Hurles.

For more information on the Cytogenetics Facility, please contact Fengtang Yang.

The observable differences are so small and rare that they are difficult to find and to prove cause and effect, and so the team works together with a large international consortium of researchers investigating inherited disorders. The team has also developed microarray technologies to reveal changes in copy number of individual genes in single cells, as well as a technique known as arraypainting that allows the rapid detection of large changes in chromosome structure associated with a variety of human disorders.

The team are also responsible for setting up the resource known as DECIPHER, which is a clinical database open to physicians all over the world into which information concerning rare genetic disorders can be entered with the purpose of sharing research findings to further the understanding of genetic diseases in man.

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Publications

  • Ultra-high resolution array painting facilitates breakpoint sequencing.

    Gribble SM, Kalaitzopoulos D, Burford DC, Prigmore E, Selzer RR et al.

    Journal of medical genetics 2007;44;1;51-8

  • High resolution array-CGH analysis of single cells.

    Fiegler H, Geigl JB, Langer S, Rigler D, Porter K et al.

    Nucleic acids research 2007;35;3;e15

  • Global variation in copy number in the human genome.

    Redon R, Ishikawa S, Fitch KR, Feuk L, Perry GH et al.

    Nature 2006;444;7118;444-54