Bird Group | Epigenetic mechanisms in health and disease

Bird Group | Epigenetic mechanisms in health and disease

Bird Group

Our Research and Approach

Cpg_island_evolution1.pngWikimedia Commons

Adrian's research group is interested in the way chemical marking of chromosomes influences genome activity in normal cells and in disease. In particular, the team focuses on:

  • The function of long non-coding RNAs originating at CpG island promoters
  • The effects of a methylated DNA binding protein on gene expression

To read more about these projects, please click on 'Read more'.

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People

Bird, Adrian
Adrian Bird
Group Leader

Adrian's research group is interested in the way chemical marking of chromosomes influences genome activity in normal cells and in disease. As a member of Associate Faculty he aims to pursue research projects in collaboration with Sanger scientists, taking advantage of the Institute's strength in large scale genetics and genomics.

Research Programmes

Partners and Funders

Internal Partners
External Partners and Funders

Publications

  • Rett syndrome: a complex disorder with simple roots.

    Lyst MJ and Bird A

    Nature reviews. Genetics 2015;16;5;261-75

  • Synthetic CpG islands reveal DNA sequence determinants of chromatin structure.

    Wachter E, Quante T, Merusi C, Arczewska A, Stewart F et al.

    eLife 2014;3;e03397

  • Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.

    Lyst MJ, Ekiert R, Ebert DH, Merusi C, Nowak J et al.

    Nature neuroscience 2013;16;7;898-902

  • CpG islands and the regulation of transcription.

    Deaton AM and Bird A

    Genes & development 2011;25;10;1010-22