The Sanger Institute started the zebrafish genome sequencing project in 2001 and has generated several genome assemblies of the Tuebingen strain. After the release of Zv9, the zebrafish genome project joined the Genome Reference Consortium (GRC) for further improvement and ongoing maintenance. The GRC has now released a new reference assembly, GRCz11. Our GRC partners at ZFIN have agreed to take over the responsibility for further updates and maintenance.
This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.
We explore molecular phenotypes through the transcript sequencing of whole vertebrate embryos and tissues either by traditional RNA-seq or 3' end transcript counting. Taking advantage of the high quality reference genomes of the zebrafish and mouse, we are able to capture the full complement of polyadenylated transcripts. This allows us to establish a baseline of gene expression across the development of unperturbed organisms or explore the transcriptional consequences of loss of gene function or environmental disturbance.
Our mission is to provide state-of-the-art molecular cytogenetics services to support the cutting-edge research of the institute.
Clones that have been generated for the genome project can be ordered as specified below:
This library is unfortunately not available anymore, please contact firstname.lastname@example.org for alternatives
Data Release Policy
The Zebrafish Genomes Project releases sequence data and variant calls as a service to the research community. These data are released in accordance with the Fort Lauderdale agreement and Toronto agreements. As producers of these data we reserve the right to be the first to publish a genome-wide analysis of the data we have generated. The pre-publication data that we release via this website is embargoed for publication except for analyses of single chromosomes in single strains or single gene loci across multiple strains. We strongly encourage researchers to contact us if there are any queries about referencing or publishing analysis based on pre-publication data obtained via this website. More information on the Wellcome Trust Sanger Institute's data sharing policy.
If you have a query about using the project data in your studies or publications, we are happy to answer any queries and can be contacted at email@example.com