The Sanger Mouse Genetics Programme (Sanger MGP) was initiated in 2006 to advance the functional understanding of protein coding and non-coding RNA genes using a standardised high-throughput phenotypic screen designed to contribute to improved diagnosis and treatment of human disease.
About the Partnership
Production of strains
The Wellcome Trust Sanger Institute generates mutant mouse strains from the ES cell resources:
European Conditional Mouse Mutagenesis (EUCOMM) Program
EUCOMM: Tools for Functional Annotation of the Mouse Genome (EUCOMMTools) Project which includes the production of Cre driver lines (CREATE)
CRISPR technology is also used to generate mutant mouse lines.
Distribution of strains
Registration of Interest (RoI): Potentially early opportunity to source a new mouse line from the Sanger Institute whilst being actively bred on the shelf for the primary phenotyping if available. Interest may be submitted at Infrafrontier.