Mouse Resource Portal

The Sanger Mouse Genetics Programme (Sanger MGP) was initiated in 2006 to advance the functional understanding of protein coding and non-coding RNA genes using a standardised high-throughput phenotypic screen designed to contribute to improved diagnosis and treatment of human disease.

About the Partnership

Production of strains



Genome Research Limited

The Wellcome Trust Sanger Institute generates mutant mouse strains from the ES cell resources:

  • European Conditional Mouse Mutagenesis (EUCOMM) Program
  • EUCOMM: Tools for Functional Annotation of the Mouse Genome (EUCOMMTools) Project which includes the production of Cre driver lines (CREATE)
  • Knockout Mouse Project (KOMP)

CRISPR technology is also used to generate mutant mouse lines.

Distribution of strains
  • Registration of Interest (RoI): Potentially early opportunity to source a new mouse line from the Sanger Institute whilst being actively bred on the shelf for the primary phenotyping if available. Interest may be submitted at Infrafrontier.​

Service fee for the supply of the mice.

For general enquiries about sourcing a mouse line please contact mouseinterest@sanger.ac.uk

Repositories: The mutant mouse lines are archived and deposited for long term distribution and may be sourced from Infrafrontier, KOMP Repository  and MMRRC Repository

Phenotyping of strains

Primary phenotyping data for the mutant mouse lines screened is displayed at:

  • International Mouse Phenotyping Consortium (IMPC)
  • Deciphering the Mechanisms of Developmental Disorders (DMDD)
  • Origins of Bone and Cartilage Disease(OBCD)
  • Infection and Immunity Immunophenotyping (3i)

For general enquiries about phenotyping please contact MGPEnquiries@sanger.ac.uk

Funding

Funding for the production and archiving of mutant mouse lines by the Sanger Institute was provided by:

  • Wellcome Trust (grants [079643], [098051]),
  • National Institutes of Health (KOMP; awards [UO1-HG004080]; [1-U42RR033192])
  • European Commission
    • EUMODIC (contract [LSHG-CT-2006-037188])
    • EMMAService (grant [227490])
    • Infrafrontier-I3 (grant [312325])
    • EUCOMMTools (grant [261492]).

Publications

  • Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach.

    Scavizzi F, Ryder E, Newman S, Raspa M, Gleeson D et al.

    Transgenic research 2015;24;5;921-7

  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

    Hrabě de Angelis M, Nicholson G, Selloum M, White JK, Morgan H et al.

    Nature genetics 2015;47;9;969-78

  • A gene expression resource generated by genome-wide lacZ profiling in the mouse.

    Tuck E, Estabel J, Oellrich A, Maguire AK, Adissu HA et al.

    Disease models & mechanisms 2015;8;11;1467-78

  • Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.

    DiTommaso T, Jones LK, Cottle DL, WTSI Mouse Genetics Program, Gerdin AK et al.

    PLoS genetics 2014;10;10;e1004705

  • Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.

    Liakath-Ali K, Vancollie VE, Heath E, Smedley DP, Estabel J et al.

    Nature communications 2014;5;3540

  • Rapid conversion of EUCOMM/KOMP-CSD alleles in mouse embryos using a cell-permeable Cre recombinase.

    Ryder E, Doe B, Gleeson D, Houghton R, Dalvi P et al.

    Transgenic research 2014;23;1;177-85

  • Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.

    Ryder E, Gleeson D, Sethi D, Vyas S, Miklejewska E et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2013;24;7-8;286-94

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.

    Ryder E, Wong K, Gleeson D, Keane TM, Sethi D et al.

    Genesis (New York, N.Y. : 2000) 2013;51;7;523-8

  • Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.

    Bassett JH, Gogakos A, White JK, Evans H, Jacques RM et al.

    PLoS genetics 2012;8;8;e1002858