Clinical microbiology translation
About the Partnership
Bacterial whole genome sequencing provides the ultimate level of resolution for transmission tracking, and can be used to predict drug resistance. Rapid sequencing therefore has considerable potential for use in clinical mirobiology for outbreak detection and resistance analysis. We are working with groups in Cambridge and Oxford to enable this.
Sanger team partners
Partners and Funders
Early insights into the potential of the Oxford Nanopore MinION for the detection of antimicrobial resistance genes.
The Journal of antimicrobial chemotherapy 2015;70;10;2775-8
Evolutionary dynamics of methicillin-resistant Staphylococcus aureus within a healthcare system.
Genome biology 2015;16;81
Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting.
Genome research 2015;25;1;111-8
Zero tolerance for healthcare-associated MRSA bacteraemia: is it realistic?
The Journal of antimicrobial chemotherapy 2014;69;8;2238-45
Rapid single-colony whole-genome sequencing of bacterial pathogens.
The Journal of antimicrobial chemotherapy 2014;69;5;1275-81
Whole-genome sequencing for rapid susceptibility testing of M. tuberculosis.
The New England journal of medicine 2013;369;3;290-2
Rapid bacterial whole-genome sequencing to enhance diagnostic and public health microbiology.
JAMA internal medicine 2013;173;15;1397-404
Rapid whole-genome sequencing for investigation of a suspected tuberculosis outbreak.
Journal of clinical microbiology 2013;51;2;611-4
Routine use of microbial whole genome sequencing in diagnostic and public health microbiology.
PLoS pathogens 2012;8;8;e1002824
Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak.
The New England journal of medicine 2012;366;24;2267-75
Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.
The Lancet. Infectious diseases 2015;15;10;1193-202
Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study.
The Lancet. Infectious diseases 2013;13;2;137-46