GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Common variants at 30 loci contribute to polygenic dyslipidemia.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
abca1a ABCA1 ENSDARG00000074635 9 Not determined 13
abcg8 ABCG8 ENSDARG00000063059 4 Not determined 4
angptl3 ANGPTL3 ENSDARG00000044365 None Not determined 7
apoa1 APOA1 ENSDARG00000012076 1 Not determined 13
apoa1 APOA4 ENSDARG00000012076 1 Not determined 11
apoa1 APOA5 ENSDARG00000012076 1 Not determined 22
apoa4 APOA1 ENSDARG00000040298 1 Not determined 13
apoa4 APOA4 ENSDARG00000040298 1 Not determined 11
apoa4 APOA5 ENSDARG00000040298 1 Not determined 22
apob APOB ENSDARG00000042780 7 Not determined 17
apobl APOB ENSDARG00000022767 6 Not determined 17
apoeb APOE ENSDARG00000040295 None Not determined 42
celsr1a CELSR2 ENSDARG00000069185 3 Not determined 17
CELSR2 CELSR2 ENSDARG00000088231 3 Not determined 17
celsr2l CELSR2 ENSDARG00000019726 1 Not determined 17
cetp CETP ENSDARG00000030872 1 Not determined 27
fads2 FADS2 ENSDARG00000019532 None Not determined 15
hmgcra HMGCR ENSDARG00000052734 1 Not determined 9
hmgcrb HMGCR ENSDARG00000059301 1 Not determined 9
hnf1a HNF1A ENSDARG00000009470 None Not determined 21
hnf4a HNF4A ENSDARG00000021494 None Not determined 8
ldlr LDLR ENSDARG00000029476 1 Not determined 15
LDLR (2 of 2) LDLR ENSDARG00000089730 None Not determined 15
lipc LIPC ENSDARG00000053476 2 Not determined 24
LIPC (2 of 2) LIPC ENSDARG00000090486 None Not determined 24
lipg LIPG ENSDARG00000031044 1 Not determined 9
LOC100331214 LPL ENSDARG00000034667 None Not determined 21
LOC100333044 GCKR ENSDARG00000086620 None Not determined 39
LOC793137 LCAT ENSDARG00000062375 None Not determined 6
lpl LPL ENSDARG00000087697 1 Not determined 21
LPL (1 of 2) LPL ENSDARG00000091659 None Not determined 21
mafba MAFB ENSDARG00000017121 None Not determined 5
mafbb MAFB ENSDARG00000070542 1 Not determined 5
mmab MMAB ENSDARG00000068344 1 Not determined 4
mvk MVK ENSDARG00000004130 None Not determined 4
ncana NCAN ENSDARG00000067820 1 Not determined 4
ncanb NCAN ENSDARG00000005783 1 Not determined 4
pbx4 PBX4 ENSDARG00000052150 None Not determined 4
PBX4 (1 of 2) PBX4 ENSDARG00000091547 None Not determined 4
PCSK9 PCSK9 ENSDARG00000074185 1 Not determined 10
pltp PLTP ENSDARG00000035768 1 Not determined 5
si:ch1073-189o9.1 MLXIPL ENSDARG00000089107 None Not determined 13
si:ch211-212d10.4 CILP2 ENSDARG00000013687 2 Not determined 5
si:dkey-159a18.1 SORT1 ENSDARG00000056145 1 Not determined 13
si:dkey-162b3.1 GALNT2 ENSDARG00000003829 4 Not determined 8
si:dkey-205h13.2 CILP2 ENSDARG00000089429 1 Not determined 5
si:dkey-222k23.2 TIMD4 ENSDARG00000091692 None Not determined 2
si:dkey-222k23.2 HAVCR1 ENSDARG00000091692 None Not determined 2
si:dkey-222k23.4 HAVCR1 ENSDARG00000077257 2 Not determined 2
si:dkey-222k23.4 TIMD4 ENSDARG00000077257 2 Not determined 2
si:dkey-258f14.3 LDLR ENSDARG00000075974 None Not determined 15
si:dkey-30k22.7 CELSR2 ENSDARG00000037286 3 Not determined 17
si:dkey-7f3.15 APOA1 ENSDARG00000094929 None Not determined 13
si:dkey-7f3.15 APOA4 ENSDARG00000094929 None Not determined 11
si:dkey-7f3.15 APOA5 ENSDARG00000094929 None Not determined 22
si:dkeyp-106c3.3 APOB ENSDARG00000093159 None Not determined 17
si:dkeyp-88f5.1 APOB ENSDARG00000075016 3 Not determined 17
si:rp71-39b20.7 ANGPTL4 ENSDARG00000035859 1 Not determined 2
sort1a SORT1 ENSDARG00000029402 None Not determined 13
sort1b SORT1 ENSDARG00000056252 7 Not determined 13
trib1 TRIB1 ENSDARG00000076142 1 Not determined 12
xkr6 XKR6 ENSDARG00000043410 2 Not determined 3
XKR6 (2 of 2) XKR6 ENSDARG00000020443 None Not determined 3
zgc:110064 APOE ENSDARG00000086370 None Not determined 42
zgc:112992 APOA4 ENSDARG00000086281 None Not determined 11
zgc:112992 APOA5 ENSDARG00000086281 None Not determined 22
zgc:112992 APOA1 ENSDARG00000086281 None Not determined 13
zgc:171581 ABCA1 ENSDARG00000079009 5 Not determined 13
zgc:194131 APOA1 ENSDARG00000020866 2 Not determined 13
zgc:194131 APOA4 ENSDARG00000020866 2 Not determined 11
zgc:194131 APOA5 ENSDARG00000020866 2 Not determined 22
zgc:92647 HAVCR1 ENSDARG00000040178 None Not determined 2
zgc:92647 TIMD4 ENSDARG00000040178 None Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • AMAC1L2
  • APOC1
  • APOC2
  • APOC3
  • APOC3
  • APOC4
  • FADS1
  • FADS1
  • FADS3
  • FADS3
  • PSRC1
  • TTC39B
* quick link - http://q.sanger.ac.uk/kpe77yqk