Mouse resource portal
Unified access to major mouse resources from the Institute or its collaborators, including BACs, gene targeting vectors, targeted embryonic stem (ES) cells, mutant mouse lines, and phenotypic data.
Access by resource type
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Current projects
- Ensembl - Access to the genome from the latest Ensembl assembly.
- Mouse Genomes Project - Genomic sequences from mouse strains.
- Genome Reference Consortium - The Genome Reference Consortium was formed to improve the representation of the human reference assembly.
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Legacy projects
- Mouse Genome Project - Sanger Institute and the mouse genome project.
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Small sequencing projects
- NOD - Insulin-dependent diabetes in the non-obese diabetic (NOD) mouse.
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Vectors and clones
- MICER - MICER (Mutagenic Insertion and Chromosome Engineering Resource) is a genome-wide collection of targeting vectors for chromosome engineering and gene-targeting.
- HTGT - Targeting vectors from our high-throughput gene targeting pipeline for the construction of plasmid-sized conditional gene targeting constructs.
- bMQ and BACs - Contact information to request clones from our mouse genome programmes.
Contact information for clone requests from our mouse genome programmes.
- Cells lines
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Mouse lines and phenotyping
- Mouse cell lines and phenotype data are available from our Mouse resource portal.
Access by resource programme
- High throughput gene targeting - As part of the international knockout mouse consortium, we have established a high-throughput pipeline to generate conditional targeted mutations in C57BL/6 ES cells.
- Sanger Institute Gene Trap Resource - The Institute’s Gene Trap Resource has more than 10,000 characterised lacZ-tagged insertional mutations in 129 ES cells.
- MICER - (Mutagenic Insertion and Chromosome Engineering Resource) is a genome-wide collection of targeting vectors for chromosome engineering and gene-targeting.
Mouse laboratories
- Mouse genomics - Uses disruption of genes in ES cells in mice to discover genes involved in cellular processes and diseases.
- Genetics of deafness - Studies mice with hearing impairments to identify genes associated with deafness and determines their function.
- Genes to cognition - Carries out genome wide and specific gene studies to understand synapse and multiprotein machines.
- Mouse cancer genetics - Studies cancer genes to develop a rational database to delineate the pathways required for the tumour development.
- Mouse developmental genetics - Establishes gene-based, phenotype-driven screens in mouse ES cells that will add an important new dimension to the functional annotation of mammalian genes.
- Experimental cancer genetics - Understands mechanisms of cancer development by generating and characterising mutations in mice.