Mouse resource portal
Unified access to major mouse resources from the Institute or its collaborators, including BACs, gene targeting vectors, targeted embryonic stem (ES) cells, mutant mouse lines, and phenotypic data.
Access by resource programme
- High throughput gene targeting - A high-throughout gene targeting pipeline to generate conditional targeted mutations in C57BL/6 ES cells.
- Sanger Institute Gene Trap Resource (SIGTR) - More than 10,000 characterised lacZ-tagged insertional mutations in 129 ES cells.
- Mutagenic Insertion and Chromosome Engineering Resource (MICER) - A genome-wide collection of targeting vectors for chromosome engineering and gene-targeting.
- Email contacts for more information about mouse resources.
Access by resource type
Mouse lines and phenotype data
- Mouse cell lines and phenotype data are available from our Mouse resource portal.
- Request mouse strains from the Sanger Institute Mouse Genetics Project
Mutant ES cell lines
- Request EUCOMM and KOMP knockout ES cell lines and targeting vectors from the International Knockout Mouse Consortium (IKMC)
- Request Gene trap cell lines from the Sanger Institute Gene Trap Resource (SIGTR)
Vectors and clones
- HTGT - Information on targeting vectors from our high-throughput gene targeting pipeline
- MICER - A genome-wide collection of targeting vectors for chromosome engineering and gene targeting
- bMQ and BACs - Contact information to request clones from our mouse genome programmes
- PiggyBac- Transposon systems for iPS generation and mutagenesis
Sequencing projects
- Mouse strain genome sequencing - Genomic sequences from mouse strains
- Previous mouse sequencing - Sanger Institute and the mouse genome project
- NOD - Insulin-dependent diabetes in the non-obese diabetic (NOD) mouse
- Ensembl - Access to the genome from the latest Ensembl assembly
Mouse research laboratories
- Mouse genomics - Uses disruption of genes in ES cells in mice to discover genes involved in cellular processes and diseases.
- Genetics of deafness - Studies mice with hearing impairments to identify genes associated with deafness and determines their function.
- Genes to cognition - Carries out genome wide and specific gene studies to understand synapse and multiprotein machines.
- Mouse cancer genetics - Studies cancer genes to develop a rational database to delineate the pathways required for the tumour development.
- Mouse developmental genetics - Establishes gene-based, phenotype-driven screens in mouse ES cells that will add an important new dimension to the functional annotation of mammalian genes.
- Experimental cancer genetics - Understands mechanisms of cancer development by generating and characterising mutations in mice.
